II. Indications
- Atrial Fibrillation with hemodynamic instability
- Atrial Fibrillation >48 hours on Anticoagulation for >4 to 6 weeks (or cleared of atrial thrombus by TEE)
-
Atrial Fibrillation <48 hours and not on Anticoagulation
- See precautions in Atrial Fibrillation Cardioversion
- Thromboembolism risk still exists despite short duration of Atrial Fibrillation
- Consider Transesophageal Echocardiogram prior to cardioversion
- Other required criteria
- No significant left atrial enlargement
- Left atrium >4.5 cm poorly maintains sinus rhythm
- CHADS2-VASc Score <2 in men or <3 in women
- If CHADS-VASc Score higher, avoid cardioversion unless <12 hours from known onset
- NO history of stroke or Transient Ischemic Attack in prior 6 months
- NO valvular Atrial Fibrillation (Mechanical Heart Valves, Mitral Stenosis)
- No significant left atrial enlargement
- See precautions in Atrial Fibrillation Cardioversion
III. Contraindications
- Digoxin Toxicity
-
Atrial Fibrillation without Anticoagulation (or Anticoagulation <4 weeks)
- Onset >48 hours before presentation
- History of stroke or Transient Ischemic Attack in prior 6 months
- Valvular Atrial Fibrillation (Mechanical Heart Valves, Mitral Stenosis)
- Atrial Fibrillation >48 hours with significant left atrial enlargement (left atrium >4.5 cm)
-
Atrial Fibrillation >12 hours in high risk patients (CHADS2-VASc Score >=2 in men or >=3 in women)
- Increased risk of CVA if onset >12 hours (esp. with elevated CHADS2-VASc Score)
- Andrade (2018) Can J Cardiol 34(1): 1371-92 [PubMed]
- Garg (2016) JACC Clin Electrophysiol 2(4): 487-94 [PubMed]
- Stiell (2018) Can J Emerg Med 20:334-42 [PubMed]
IV. Efficacy
- Conversion Rate: 86-94% (contrast 51% efficacy of chemical cardioversion)
- Higher success rates in Atrial Flutter than with Atrial Fibrillation
- Emergency department electrical cardioversion is safe and effective
V. Dosing
- Dose adjustments
- Adjust dose if on Digoxin (see below)
- Higher dose (200 Joules) needed in Atrial Fibrillation, whereas lower doses are effective in Atrial Flutter
- Monophasic dose
- Synchronized: 200 joules (up to 360 joules)
- Starting at monophasic 200 joules minimizes cummulative shock exposure
- Justification: 100 J dose in Atrial Fibrillation has only 50% success rate (requiring second shock)
- Biphasic dose (preferred)
- Synchronized: 150 joules (up to 200 joules)
- Consider Antiarrhythmic pre-treatment prior to cardioversion in stable patients (controversial)
- Based on anecdotal experience, may improve electrical cardioversion success rate
- Option 1: Procainamide
- Procainamide 1 gram IV over 1 hour, then Synchronized Cardioversion if needed
- See Ottawa Aggressive Protocol in Atrial Fibrillation Cardioversion
- Option 2: Amiodarone
- Amiodarone 150 mg IV, then Synchronized Cardioversion if needed
VI. Precautions: Digoxin
- Do not use electrical cardioversion in Digoxin Toxicity (risk of malignant ventricular Arrhythmia)
- Modified electrical cardioversion dosing in patients on Digoxin
- Start at 10-20 Joules biphasic
- Increase in 10-20 Joule increments until cardioversion
VII. Protocol
- Consider alternative protocol (Procainamide followed by electrical cardioversion if fails)
-
Informed Consent
- See Atrial Fibrillation Cardioversion for risks
-
Conscious Sedation
- See Synchronized Cardioversion for protocol
-
Unfractionated Heparin or Low Molecular Weight Heparin indications
- Atrial Fibrillation of unknown duration or >48 hours (emergent, unstable cases requiring immediate cardioversion) or
- High risk of Cerebrovascular Accident (e.g. prior TIA or CVA, Rheumatic Heart Disease, Mechanical Heart Valve)
VIII. Management: Post-cardioversion
- See Atrial Fibrillation Acute Management
- Describes overall approach and disposition planning (including safe for discharge indications)
-
Atrial Fibrillation Anticoagulation
- Describes indications for Anticoagulation and agents (Warfarin, Dabigatran, Oral Xa Inhibitors)
- Expert opinion typically recommends Anticoagulation for 3 weeks following cardioversion due to myocardial stunning
- Increased risk of stroke in the first 3 weeks after cardioversion
- See Atrial Fibrillation Rate Control
- Discharge patient on Metoprolol Tartrate (25 mg bid) or Metoprolol Succinate (25-50 mg daily) in most cases
IX. Complications
X. References
- Casaletto (2014) Crit Dec Emerg Med 28(4): 10-19
- Orman and Berg in Herbert (2016) EM:Rap 16(2): 6-10
- Burton (2004) Ann Emerg Med 44(1): 20-30 [PubMed]
- Stiell (2011) Canadian J Cardiol 27(1): 38-46 [PubMed]
- Wann (2011) Circulation 123(1): 104-23 [PubMed]
- King (2002) Am Fam Physician 66(2):249-56 [PubMed]
- Gutierrez (2011) Am Fam Physician 83(1): 61-8 [PubMed]
- Falk (2001) N Engl J Med 344:1067-78 [PubMed]
- Li (1998) Emerg Med Clin North Am 16:389-403 [PubMed]
- King (2002) Am Fam Physician 66:249-56 [PubMed]