II. Indications: ACA/AHA and ESC/EHRA
- Ejection Fraction <30-35%
- NYHA Class 2-4 Heart Failure despite stable optimal medical therapy
-
QRS Duration > 120 msec
- CRT did not show mortality or hospitalization benefit for QRS Duration 120-150 msec in meta-analysis
- Sipahi (2011) Arch Intern Med 171(16): 1454-62 [PubMed]
III. Contraindications
- Cardiogenic Shock
- Symptomatic Hypotension while in stable baseline rhythm
- Coronary revascularization (CABG or PTCA) within last 3 months
- Acute Myocardial Infarction within 40 days
- Clinical findings necessitating coronary revascularization
- Irreversible brain damage from cerebral disease
- Life Expectancy <1 year from other comorbidities