II. Types: Stress Testing
- Exercise Stress Test (no imaging; described on this page)
- Indicated as cost effective first-line test
- See Cardiac Stress Imaging Indications
- Consider imaging if nondiagnostic EKG is likely (uninterpretable EKG)
- Avoid non-imaging stress test if prior coronary revascularization (low sensitivity)
- Resting ST depression >1mm
- Left Bundle Branch Block
- Paced rhythm
- Digoxin
- WPW Syndrome
- Efficacy
- Test Sensitivity: 55-68%
- Test Specificity: 70-77%
- False Positive Rate: 11% in men, 17% in women
- Stress Tests with Imaging and Exercise as stressor
- See Stress Imaging
- Indications
- Stress Echocardiogram
- Most cost-effective, versatile Cardiac Imaging
- Large body habitus interferes with echo windows
- Consider Optison contrast to increase accuracy
- May be better study post-revascularization
- Lower sensitivity than Myocardial Perfusion Imaging, but much better Specificity
- Stress Echo is less likely to result in False Positive tests post-revascularization
- Efficacy
- Test Sensitivity: 64-90%
- Test Specificity: 80-87%
- Stress Myocardial Perfusion Imaging
- Diaphragm and Breast interferes with images
- Efficacy
- Test Sensitivity: 85-90%
- Test Specificity: 80-90%
-
Stress Imaging with Pharmacologic Provocation
- See Pharmacologic Stress Test
- Indicated if patient unable to Exercise 5 mets (~5 minutes on bruce protocol)
-
Dobutamine Echocardiogram
- No Beta Blockers for 24 hours before test
-
Myocardial Perfusion Imaging with Adenosine
- Avoid in severe COPD, Asthma, Carotid Stenosis
- No nitrates on day of test
- No Methylxanthines (e.g. Caffeine) for 24 hours
- Myocardial Perfusion Imaging with Dipyridamole
III. Types: Alternatives and Adjuncts to Exercise Stress Testing
-
CT Coronary Calcium
- Indicated in Intermediate CAD risk asymptomatic patients
- Angiography
- Indications
- Significantly abnormal stress test (see above)
- Symptomatic patient and high Cardiac Risk
- Types
- Indications
- Stress tests in asymptomatic patients has risks
- False Positives and unnecessary invasive testing (e.g. angiography)
- Sudden Cardiac Death or hospitalization (NNH: 10000)
IV. Indications: Asymptomatic Subjects for Exercise Stress Test
- Preoperative evaluation
- Unable to perform 4 METS of Exercise OR
- Cardiac symptoms on exertion OR
- Planned vascular surgery, or liver or Kidney Transplant
- Pre-Vigorous Exercise Program (>6 METS) evaluation in deconditioned patients with Cardiac Risk Factors
- Diabetes Mellitus OR
- Men over age 45 years old (women over age 55 years old) OR
- Two or more Cardiac Risk Factors
- Asymptomatic patietns with history of revascularization
- Percutaneous coronary interventing (stenting) >2 years prior
- Coronary Artery Bypass Graft (CABG) >5 years prior
- Other possible indications
- Special occupation
- Pilot
- Police officer
- Bus driver
- Valvular heart disease: Aortic Regurgitation
- Cardiac rhythm disorders
- Rate-adaptive Pacemaker assessment
- Sports Physical for congenital complete Heart Block
- Exercise-induced rhythm disturbance evaluation
- Pre-Hypertension Evaluation: Diagnostic criteria
- Peak systolic Blood Pressure >214 or
- High systolic Blood Pressure >3 minutes in recovery
- High diastolic pressure >3 minutes in recovery
- Special occupation
V. Indications: Symptomatic Subjects for Exercise Stress Test
- First-line study to assess CAD risk where intermediate risk
- See contraindications below
- See Angina Diagnosis to determine those with intermediate risk
- Requires normal baseline EKG (otherwise requires Stress Imaging)
- No prior revascularization procedures such as PTCA, CABG (requires Stress Imaging)
- Ability to Exercise at least 5 METS (requires Pharmacologic Stress Testing)
- No Diabetes Mellitus (requires Stress Imaging)
-
Acute Coronary Syndrome Assessment (Low Risk Chest Pain evaluation)
- Must have <1 mm resting ST depression
- Significant change in clinical status
- Atypical symptoms in men or menopausal women
- Unstable Angina without active Angina or Congestive Heart Failure
- See Acute Coronary Syndrome for risk levels
- Low Risk Chest Pain patient after 8-12 hours observation
- Intermediate risk and following criteria met
- Normal Cardiac Markers at 0 and 6 hours and
- No change in serial electorcardiograms and
- No evidence of active ischemia
- Assess patient with Exercise-induced Dysrhythmia
- Also see asymptomatic patients above
- Known Coronary Artery Disease
- Precaution
- Do not stress test if recent revascularization procedure
- Stress testing is not recommended unless change in function or acute event
- In addition, Stress Imaging is preferred if known Coronary Artery Disease
- Post-Myocardial Infarction to assess prognosis
- Submaximal stress test
- Pre-discharge: 4-6 days post-MI or
- Post-discharge: 14-21 days post-MI
- Symptom-limited stress test at 3-6 weeks post-MI
- Submaximal stress test
- Precaution
VI. Contraindications: Any Exercise Stress Test (with or without imaging)
- Myocardial Infarction in prior 2 days
- Active Endocarditis
- Acute Aortic Dissection
- Acute Myocarditis
- Acute Pericarditis
- Recent or active cerebral ischemia (TIA or CVA)
- Severe, Uncontrolled Hypertension (SBP >200 mmHg or DBP >110 mmHg)
- Uncompensated Congestive Heart Failure
- Unstable Angina
- Advanced Heart Block (Mobitz 2 or third degree AV Block)
- Critical Left Ventricular outflow-tract obstruction
VII. Contraindications: Exercise Stress Test without Imaging
- Inability to Exercise to adequate level of exertion
- Unable to perform 5 minutes on Bruce Protocol
- Unable to reach 85% of Maximal Heart Rate (220-Age)
- Consider pharacological Stress Imaging modalities
- Uninterpretable Electrocardiogram (Stress Imaging instead)
- Left Bundle Branch Block (Adenosine Nuclear scan needed)
- Electronically paced rhythm (Pacemaker)
- WPW Syndrome
- Abnormal ST Segments (>1 mm ST abnormality)
- Includes Digoxin
- Includes Left Ventricular Hypertrophy
-
Digoxin Use (Class IIB Recommendation)
- Digoxin is associated with high stress test False Positive Rate (use Stress Imaging instead)
- Cardiac revascularization within last 5 years
VIII. Protocol: Stress ExerciseGeneral
- Stress Exercise is typically performed on treadmill
- But may be performed on Exercise bike or cycle ergometer
- Preparation
- Hold all Beta Blockers 24 hours before test
- Hold nitrates (Nitroglycerin) on day of the test
IX. Protocol: Prematurely Stopping the Exercise Stress Test
- Absolute indications to stop the test
- CNS symptoms (e.g. Ataxia, Dizziness, Near Syncope)
- Despite increased workload, systolic Blood Pressure drops >10 mmHg (with symptoms of ischemia)
- Moderate to severe Angina
- Poor perfusion signs (Cyanosis, pallor)
- ST Segment Elevation >1 mm in leads without preexisting Q Waves (outside aVR, aVL, V1)
- Significant Arrhythmia (e.g. sustained Ventricular Tachycardia, second or third degree AV Block)
- Unable to continue monitoring (e.g. Blood Pressure, ekg)
- Patient asks to stop test
- Relative indications to stop the test
- Other Arrhythmias not listed above (e.g. Supraventricular Tachycardia, Bradyarrhythmias)
- Bundle Branch Block not distinguishable from Ventricular Tachycardia
- Claudication (or Fatigue or Leg Cramps)
- Wheezing or significant Shortness of Breath
- Despite increased workload, systolic Blood Pressure drops >10 mmHg (withOUT symptoms of ischemia)
- Exaggerated hypertensive response (>250/115 mmHg)
- Heart Rate 85% of expected maximum for age
- Increasing Chest Pain
- ST segment Depression (horizontal or down sloping) >2 mm with suspected ischemia
X. Interpretation: Poor prognostic findings
- Low workload
- Mets <6.5
- Time: < 5-6 minutes on Bruce protocol
- Low peak Heart Rate
- Heart Rate < 120/min without Beta-Blocker therapy
- Systolic Blood Pressure decreased or flat response
- Remains under 130 mmHg
- ST segment Depression >2mm
- ST segment Depression in multiple leads
- Prolonged ST depression after Exercise (>6 min)
- ST Elevation without abnormal Q Wave
- Increase in complex ventricular ectopy
- Exercise-induced typical Angina
- Frequent ventricular ectopy
XI. Interpretation: Predictors of mortality in women
- Decreased peak Exercise capacity
- Delayed Heart Rate recovery
- ST depression on Exercise was not related to mortality
- Mora (2003) JAMA 290:1600-7 [PubMed]
XII. Interpretation: Prognosis based on METS
- Ability to perform 6 mets on Bruce protocol is as predictive as Duke Score
- Ability to perform >10 METS on Bruce Protocol is associated with a low risk of death
XIII. Interpretation: Prognostic Duke Treadmill Score
- Background
- Score developed for patients with median age 49
- Alternatively, METS performed are predictive of prognosis (see above)
- Not predictive in patients over age 75 years
- Calculation
- Interpretation
- Low death risk: 7 or more
- Five-year survival: 93%
- Intermediate Risk: Between -10 and +5
- High death risk: Below -10
- Four-year survival 71-79%
- Low death risk: 7 or more
- References