II. Definitions
- Human Rhinovirus (HRV)
- Picornaviridae family, enterovirus genus, non-enveloped, icosehedral, single-stranded positive sense RNA virus
- Over 100 Rhinovirus serotypes have been identified since first discovered in 1950
- Rhinoviruses infect the respiratory tract and cause the Common Cold, viral Rhinosinusitis and viral Otitis Media
III. Pathophysiology
- Classification
- Picornaviridae family
- Enterovirus genus
- Structure
- Icosehedral
- Single-stranded positive sense, 7200 base pair RNA virus (ssRNA)
- Non-enveloped, but as a viral capsid of 60 copies each of 4 Proteins (VP1, VP2, VP3, VP4)
- Groups
- Group A (74 serotypes)
- Group B (25 serotypes)
- Group C (50 serotypes, identified in 2009, 40 years after the original A and B types were identified)
- Cell Binding via Cell Surface Receptors
- Intercellular Adhesion Molecule (ICAM-1, responsible for 90% of HRV binding sites)
- Low Density Lipoprotein Receptor (LDLR, minor binding site)
- Transmission
- Person to person transmission intranasal or Conjunctival via aerosol, hand to hand, or other fomite
- Survives in indoor environments at Ambient Temperature for hours to days
- Survives on undisturbed skin for 2 hours
IV. Associated Conditions
- Upper resiratory infection
- Common Cold
- Viral Rhinosinusitis
- VIral Otitis Media
- Lower Respiratory Infection (esp. Asthma, infants, elderly, Immunocompromised)
- Viral Pneumonia
- Croup
- Bronchiolitis
- COPD Exacerbation
- Asthma Pathogenesis
- Severe Bronchiolitis
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Definition (NCI) | A genus of single-stranded positive sense RNA viruses containing a single RNA molecule. The viral particles are not enveloped and are icosahedral in structure. |
Definition (CSP) | genus of viruses comprising the common cold viruses. |
Definition (MSH) | A genus of PICORNAVIRIDAE inhabiting primarily the respiratory tract of mammalian hosts. It includes over 100 human serotypes associated with the COMMON COLD. |
Concepts | Virus (T005) |
MSH | D012229 |
SnomedCT | 90389005, 186745001 |
LNC | LP17714-4 |
English | Rhinovirus, Genus: Common cold virus group, Common cold virus group, rhinovirus, rhinoviruses, Genus Rhinovirus (organism), Genus Rhinovirus, Rhinoviruses, Common cold virus group, NOS, Rhinovirus, NOS, Rhinovirus (organism) |
Swedish | Rhinovirus |
Czech | Rhinovirus |
Finnish | Rinovirus |
Russian | RINOVIRUS, OBSHCHEI PROSTUDY VIRUS, KORIZAVIRUSY, ZARAZNOGO NASMORKA VIRUS, VIRUSY KORIZY, RINOVIRUS CHELOVEKA TIP 1A, RHINOVIRUS H-1A, ВИРУСЫ КОРИЗЫ, ЗАРАЗНОГО НАСМОРКА ВИРУС, КОРИЗАВИРУСЫ, ОБЩЕЙ ПРОСТУДЫ ВИРУС, РИНОВИРУС, РИНОВИРУС ЧЕЛОВЕКА ТИП 1А |
Polish | Wirusy nieżytu nosa, Rhinovirus, Rynowirusy, Rinowirusy, Wirusy choroby przeziębieniowej |
Spanish | grupo de virus del resfrío común, género Rhinovirus, género Rhinovirus (organismo), rinovirus, Rinovirus, rinovirus (organismo), Rhinovirus |
Norwegian | Not Translated[Rhinovirus] |
French | Rhinovirus |
German | Rhinovirus |
Italian | Rhinovirus |
Dutch | Coryzavirussen, Rhinovirus |
Portuguese | Rhinovirus |