II. Definitions

  1. Human Rhinovirus (HRV)
    1. Picornaviridae family, enterovirus genus, non-enveloped, icosehedral, single-stranded positive sense RNA virus
    2. Over 100 Rhinovirus serotypes have been identified since first discovered in 1950
    3. Rhinoviruses infect the respiratory tract and cause the Common Cold, viral Rhinosinusitis and viral Otitis Media

III. Pathophysiology

  1. Classification
    1. Picornaviridae family
    2. Enterovirus genus
  2. Structure
    1. Icosehedral
    2. Single-stranded positive sense, 7200 base pair RNA virus (ssRNA)
    3. Non-enveloped, but as a viral capsid of 60 copies each of 4 Proteins (VP1, VP2, VP3, VP4)
  3. Groups
    1. Group A (74 serotypes)
    2. Group B (25 serotypes)
    3. Group C (50 serotypes, identified in 2009, 40 years after the original A and B types were identified)
  4. Cell Binding via Cell Surface Receptors
    1. Intercellular Adhesion Molecule (ICAM-1, responsible for 90% of HRV binding sites)
    2. Low Density Lipoprotein Receptor (LDLR, minor binding site)
  5. Transmission
    1. Person to person transmission intranasal or Conjunctival via aerosol, hand to hand, or other fomite
    2. Survives in indoor environments at Ambient Temperature for hours to days
    3. Survives on undisturbed skin for 2 hours

IV. Associated Conditions

  1. Upper resiratory infection
    1. Common Cold
    2. Viral Rhinosinusitis
    3. VIral Otitis Media
  2. Lower Respiratory Infection (esp. Asthma, infants, elderly, Immunocompromised)
    1. Viral Pneumonia
    2. Croup
    3. Bronchiolitis
    4. COPD Exacerbation
    5. Asthma Pathogenesis
    6. Severe Bronchiolitis

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Ontology: Rhinovirus (C0035473)

Definition (NCI) A genus of single-stranded positive sense RNA viruses containing a single RNA molecule. The viral particles are not enveloped and are icosahedral in structure.
Definition (CSP) genus of viruses comprising the common cold viruses.
Definition (MSH) A genus of PICORNAVIRIDAE inhabiting primarily the respiratory tract of mammalian hosts. It includes over 100 human serotypes associated with the COMMON COLD.
Concepts Virus (T005)
MSH D012229
SnomedCT 90389005, 186745001
LNC LP17714-4
English Rhinovirus, Genus: Common cold virus group, Common cold virus group, rhinovirus, rhinoviruses, Genus Rhinovirus (organism), Genus Rhinovirus, Rhinoviruses, Common cold virus group, NOS, Rhinovirus, NOS, Rhinovirus (organism)
Swedish Rhinovirus
Czech Rhinovirus
Finnish Rinovirus
Russian RINOVIRUS, OBSHCHEI PROSTUDY VIRUS, KORIZAVIRUSY, ZARAZNOGO NASMORKA VIRUS, VIRUSY KORIZY, RINOVIRUS CHELOVEKA TIP 1A, RHINOVIRUS H-1A, ВИРУСЫ КОРИЗЫ, ЗАРАЗНОГО НАСМОРКА ВИРУС, КОРИЗАВИРУСЫ, ОБЩЕЙ ПРОСТУДЫ ВИРУС, РИНОВИРУС, РИНОВИРУС ЧЕЛОВЕКА ТИП 1А
Polish Wirusy nieżytu nosa, Rhinovirus, Rynowirusy, Rinowirusy, Wirusy choroby przeziębieniowej
Spanish grupo de virus del resfrío común, género Rhinovirus, género Rhinovirus (organismo), rinovirus, Rinovirus, rinovirus (organismo), Rhinovirus
Norwegian Not Translated[Rhinovirus]
French Rhinovirus
German Rhinovirus
Italian Rhinovirus
Dutch Coryzavirussen, Rhinovirus
Portuguese Rhinovirus