Generalized Lymphadenopathy

Aka: Generalized Lymphadenopathy, Lymphadenopathy Causes, Lymphadenitis Causes

advertisement

II. Definitions

  1. Generalized Lymphadenopathy
    1. Lymph Node swelling affecting 2 or more non-contiguous lymph regions

III. Epidemiology

  1. Generalized Lymphadenopathy represents 25% of Lymphadenopathy Causes

IV. Causes: Infectious Causes of Lymphadenopathy

  1. Common Infectious Causes
    1. Infectious Mononucleosis (Epstein-Barr Virus)
    2. Toxoplasmosis
    3. Cytomegalovirus
    4. Cat Scratch Disease (Cat Scratch Fever, Bartonella)
    5. Upper Respiratory Infections (e.g. Pharyngitis, Adenovirus)
    6. Tuberculosis
    7. Scarlet Fever
    8. Scabies
    9. Herpes Zoster virus (Shingles)
    10. Cellulitis, Impetigo and other Skin Infections (Streptococcus and Staphylococcus)
  2. Sexually Transmitted Disease Causes of Lymphadenopathy
    1. Hepatitis B
    2. Acute Retroviral Syndrome in HIV Infection
    3. See Lymphadenopathy in HIV
    4. Primary Syphilis and Secondary Syphilis
    5. Lymphogranuloma venereum
    6. Chancroid
  3. Less Common Infectious Causes
    1. Miscellaneous fungal and Helminth infections
    2. Fungal Lung Infections (Histoplasmosis, Coccidioidomycosis, Cryptococcosis)
    3. Lyme Disease
    4. Rocky Mountain Spotted Fever (and other Rickettsia infection)
    5. Measles
    6. Rubella
    7. Tularemia
    8. Brucellosis
    9. Bubonic Plague
    10. Typhoid Fever
    11. Scrub Typhus
    12. African Trypanosomiasis (African Sleeping Sickness)
    13. Chagas' Disease
    14. Kala-azar
    15. Sporotrichosis

V. Causes: Collagen Vascular Causes of Lymphadenopathy

  1. Common
    1. Systemic Lupus Erythematosus
    2. Rheumatoid Arthritis
    3. Sjogren Syndrome
  2. Less Common
    1. Still's Disease
    2. Dermatomyositis
    3. Sarcoidosis

VI. Causes: Neoplastic Causes of Lymphadenopathy

  1. Hodgkin's Lymphoma
  2. Lymphosarcoma
  3. Histiocytic Medullary Reticulosis
  4. Leukemia
    1. Lymphocytic Leukemia
    2. Myelocytic Leukemia
  5. Metastatic cancer
    1. Melanoma and other Skin Cancers
    2. Kaposi's Sarcoma
    3. Neuroblastoma
    4. Seminoma
    5. Lung Cancer
    6. Breast Cancer
    7. Prostate Cancer
    8. Renal carcinoma
    9. Head and neck cancers
    10. Gastrointestinal Tract cancers

VII. Causes: Miscellaneous Causes of Lymphadenopathy

  1. Common
    1. Serum Sickness
    2. Sarcoidosis
    3. Hyperthyroidism
  2. Less Common
    1. Kawasaki Disease
    2. Amyloidosis
    3. Niemann-Pick Disease
    4. Gaucher's Disease
    5. Beryllioisis
    6. Silicosis
    7. Angiofollicular Lymph Node hyperplasia (Castleman Disease)
    8. Histiocytosis
    9. Kituchi Lymphadenitis
    10. Kimura Disease

VIII. References

  1. Degowin (1987) Diagnostic Exam, Macmillan, p. 467
  2. Dornbland (1992) Adult Ambulatory Care, p. 662-7
  3. Wilson (1991) Harrison's Internal Medicine, p. 354-6
  4. Lee (1999) Wintrobe's Hematology, p. 1826-30
  5. Falk (2025) Am Fam Physician 112(3): 286-93 [PubMed]
  6. Ferrer (1998) Am Fam Physician 58(6): 1313-2 [PubMed]
  7. Gaddey (2016) Am Fam Physician 94(11): 896-903 [PubMed]
  8. Libman (1987) J Gen Intern Med 2(1):48-58 [PubMed]

Images: Related links to external sites (from Bing)

These images are a random sampling from a Bing search on the term "Generalized Lymphadenopathy." Click on the image (or right click) to open the source website in a new browser window. Search Bing for all related images

Related Topics in Lymphatic Disorders

advertisement