II. Types: Hodgkin's Lymphoma

  1. Incidence mildly increased in HIV
  2. Course may be more aggressive in HIV
  3. May have less complete response to Chemotherapy

III. Types: Non-Hodgkin's Lymphoma

  1. Occurs when median CD4=200 cells
  2. Rapid tumor growth with extranodal disease
  3. Non-lymphatic sites: Lung, GI, Bone Marrow, Meninges
  4. Usually widespread (stage 4) at time of diagnosis
  5. Poor prognosis in patients with advanced HIV
  6. Median duration of survival is 3-6 months
  7. Associated with EBV viral gene sequence (40%)

IV. Types: Non-Hodgkin's Lymphoma - Primary CNS

  1. Occurs in advanced AIDS (CD4 Count<50 cells)
  2. Highly Associated with EBV viral gene sequence
  3. Space occupying unifocal intracranial lesion
    1. May be confused with CNS Toxoplasmosis
  4. Survival without treatment is 3 months
  5. Response to treatment in 50% of cases

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