II. Definitions
- Auto-PEEP (Breath Stacking, Dynamic Hyperinflation, Intrinsic PEEP)
- Breath Stacking occurs when inadequate expiratory time before next breath (esp. Obstructive Lung Disease)
- Breath Stacking builds increased intrathoracic pressure and prevents right heart filling
- Plateau Pressure
- Plateau pressures should be kept <30 cm H2O (especially in ARDS) to prevent Barotrauma
- Contrast with Peek pressures which reflect only the airway pressures needed to expand lung
- Check by depressing inspiratory hold button
- Measures pressure at the alveoli immediately before expiration
- Plateau pressures should be kept <30 cm H2O (especially in ARDS) to prevent Barotrauma
III. Causes: Acute Respiratory Deterioration on Ventilator (DOPES Mnemonic)
- Dislodged or displaced Endotracheal Tube or deflated cuff
- Obstructed Endotracheal Tube (e.g. mucous plugging, blood in tube)
- Pneumothorax
- Equipment failure (Ventilator, tubing)
- Stacking of breaths (incomplete exhalation in Asthma or COPD)
IV. Approach: High plateau pressure, High Peak pressure and Ventilator Alarms
- Heed Ventilator Alarms!
- Treat as critical incident that needs rapid response and evaluation
- If problem cannot easily be detected
- Disconnect Ventilator
- Provide bag-valve-mask PPV while troubleshooting
- Provide High Flow Oxygen (with PEEP Valve if needed)
- High peak pressure alone cannot distinguish cause
- Plateau pressure must be obtained to understand cause, and direct management
- High airway resistance (e.g. Asthma, mucous plugging) can result in exceeding inspiratory peak pressure
- The Ventilator stops ventilating and alarms immediately when peak pressure exceeds the pressure limit
- Pressure limit set too low for current peak pressures results in hypoventilation (with hypercarbia risk)
- Pressure limit typically defaults to 40 cm H2O but can be increased if peak pressure is high
- Plateau pressure (alveolar pressure) IS a risk of Barotrauma, NOT peak pressure
- To obtain plateau pressure, press and hold the "inspiratory hold/pause" button through a ventilation
- Plateau pressure >30 cm H2O (Barotrauma risk)
- Consider causes of increased plateau pressures
- ET in right mainstem
- Pneumothorax
- Increased Lung Volumes with alveolar overdistention
- Abdominal Distention with thoracic compression
- Decreased chest wall compliance
- Decrease Tidal Volume
- May decrease Tidal Volume as low as 4 ml/kg
- Risk of hypercapnia due to decreased Minute Ventilation
- However, permissive hypercapnia is preferred
- Decrease PEEP
- Risk of decreased oxygenation and alveolar collapse
- Increase Expiratory Time (e.g. shorter breaths or slower rate, decreases Auto-PEEP risk)
- Decreasing Respiratory Rate may also decrease pressure if Breath Stacking (Auto-PEEP)
- Risk of hypercapnia
- Address reversible factors impeding Lung Compliance
- Increase Post-Intubation Sedation and Analgesia
- Consider chemical paralysis (e.g. Rocuronium, cistracuronium)
- Consider changing Ventilator mode
- Change Ventilator to Pressure Cycled (PC) Ventilation
- Pathology specific strategies
- Lung Injury
- Decrease Tidal Volume until plateau pressure <30 cm H2O
- Obstructive Lung (Breath Stacking)
- Decrease Respiratory Rate until plateau pressure <30 cm H2O
- Lung Injury
- Consider causes of increased plateau pressures
- Plateau pressure <30 cm H2O (despite increased peak pressure)
- Increased PIP with normal pPLAT reflects increased airway resistance
- Reduce airway resistance (suctioning, check ET Tube position, Bronchodilators)
- Evaluate for Endotracheal Tube obstruction
- Consider kinked tubes
- Suction for mucous plugs
- Consider bronchospasm
- Evaluate for dessynchrony with Ventilator
- Evaluate for Endotracheal Tube obstruction
- Consider increasing the Ventilator pressure limit (caution!)
- References
- Weingart in Majoewsky (2013) EM:Rap 13(1): 6-7
- Orman and Mallemat in Herbert (2015) EM:Rap 15(10): 13-16
V. Approach: Auto-PEEP (Breath Stacking, Dynamic Hyperinflation, Intrinsic PEEP)
- Intrinsic PEEP (Auto-PEEP) is generated by the patient and Ventilator
- Contrast with extrinsic PEEP that is intentionally set and generated by Ventilator
- Auto-PEEP occurs with Breath Stacking
- Inadequate expiratory time before next breath (esp. Obstructive Lung Disease)
- Breath Stacking builds increased intrathoracic pressure and prevents right heart filling
- Increased Lung Volumes result in over-stretch and secondary lung injury
- Patients with hyperinflated lungs are also unable to trigger a ventilated breath
- Check by depressing Ventilator expiratory hold button
- Auto-PEEP is present if the end-expiratory pressure exceeds the VentilatorPEEP setting
- Flow-Time waveform will remain below baseline at the end of expiration
- Measures to decrease Breath Stacking and Auto-PEEP
- Optimize Obstructive Lung Disease (e.g. Bronchdilator nebulizer treatments)
- Increase expiratory time
- Decrease Respiratory Rate
- Decrease inspiratory time (increase inspiratory flow rate)
- Decrease Tidal Volume
- Decrease Tachypnea (triggered breaths) by treating pain and anxiety
VI. Approach: Acute Respiratory Deterioration on Ventilator (categorized by peak inspiratory pressure)
- Peak Inspiratory Pressure Decreased
- Air Leak
- Hyperventilation
- Peak Inspiratory Pressure Unchanged
- Pulmonary Embolism
- Extrathoracic problem
- Peak Inspiratory Pressure Increased
- Plateau Pressure unchanged: Airway Obstruction
- Aspiration
- Bronchospasm
- Secretions
- Endotracheal Tube obstruction
- Plateau Pressure increased (>30 cm H2O): Decreased Compliance (see management as above)
- Abdominal Distention
- Asynchronous breathing
- Atelectasis
- Auto-PEEP (inadequate expiration time with air trapping or stacked breaths, esp. Asthma)
- Tachypnea is primary problem with secondary excessive Respiratory Alkalosis
- Start by lowering Tidal Volume
- Consider decreasing Respiratory Rate to allow greater exhalation (reducing Breath Stacking)
- May also increase flow rates, to deliver Tidal Volume faster (longer expiration time)
- Pneumonia
- Pneumothorax
- Pulmonary Edema
- Plateau Pressure unchanged: Airway Obstruction
VII. Approach: Hypotension in the intubated Patient
-
Tension Pneumothorax
- First consideration in a newly hypotensive patient on Mechanical Ventilation
- Emergent Needle Thoracostomy followed by Chest Tube
- Auto-PEEP (Breath Stacking, Dynamic Hyperinflation)
- Decrease Tidal Volume
- Increase expiratory time by decreasing Respiratory Rate or decreasing inspiratory time
- Increased intrathoracic pressure
- Volume Resuscitation
-
Myocardial Infarction
- Consider serial Electrocardiogram and Troponin
VIII. Approach: Refractory Hypercapnic Respiratory Failure
- Indications
- Appropriate Ventilator settings with PaCO2 is higher than target (with pH<7.2
- First increase Respiratory Rate (RR)
- Exercise caution in Obstructive Lung Disease due to risk of Breath Stacking
- Correct asynchrony ("bucking the vent")
- Address Air Hunger (low Minute Ventilation or PEEP)
- Address underlying causes (e.g. pain, anxiety, Alcohol Withdrawal)
- Other measures
- Correct Electrolyte disturbance (Hypokalemia, Hypophosphatemia)
- Heliox (decreases lung hyperinflation)
- Paralysis with Neuromuscular Blockade (e.g. Rocuronium, cistracuronium)
- Precaution: Requires Deep Sedation!
- VV-ECMO
IX. Approach: Refractory Hypoxemic Respiratory Failure
- Precautions
- Avoid hyperoxia
- Risk of difficult weaning, worsening shock, liver failure, bacteremia, increased mortality
- Avoid corrective strategies that increase Breath Stacking
- Avoid hyperoxia
- Troubleshoot the Ventilator
- See DOPES Mnemonic as above
- See Acute Respiratory Deterioration on Ventilator above
- Increase oxygenation
- Other measures
- Paralysis with Neuromuscular Blockade (e.g. Rocuronium, cistracuronium)
- Precaution: Requires Deep Sedation!
- Prone Positioning
- As an alternative in resource limited areas, "good" lung may be positioned down (lateral decubitus)
- Increased inspiratory time on Ventilator
- VV-ECMO
- Paralysis with Neuromuscular Blockade (e.g. Rocuronium, cistracuronium)
X. Approach: Trouble-Shooting Inadequate Ventilation or Oxygenation (DOTTS Mnemonic)
- Disconnect the Ventilator
- Listen over the ET Tube for hissing sound
- Hissing suggests release of hyperinflated air from Breath Stacking
- If hissing present
- Apply anterior chest pressure gently for 10 seconds to assist with further release of stacked air
- Oxygenation
- Connect Ambu Bag with 100% FIO2 and provide manual Positive Pressure Ventilation
- Attach PEEP Valve if >5 cm H2O (set to Ventilator setting)
- Assess Lung Compliance
- Difficult Positive Pressure Ventilation (PPV)
- Endotracheal Tube obstruction or airway obstruction (e.g. aspiration) OR
- Decreased Lung Compliance (e.g. Acute Pulmonary Edema, Pneumothorax)
- Easy Positive Pressure Ventilation (PPV)
- Air leak (e.g. deflated ET cuff or dislodged tube)
- Difficult Positive Pressure Ventilation (PPV)
- Connect Ambu Bag with 100% FIO2 and provide manual Positive Pressure Ventilation
- Tube Position or Function
- Compare tube position to prior reading
- Pass suction catheter via the Endotracheal Tube to relieve mucous plugging
- Tweak the Ventilator setting
- Consider Breath Stacking (Auto-PEEP)
- Consider lowering Respiratory Rate and Tidal Volume
- Sonography
- See Lung Ultrasound for Pneumothorax (Sliding Lung Sign)
- See Lung Ultrasound
- See Blue Protocol (Lichtenstein Dyspnea Evaluation by Ultrasound Protocol)
- See Volpicelli Dyspnea Evaluation with Ultrasound Protocol
- Unclear if Ultrasound can reliably determine ET position in relation to carina
XI. References
- Hamm (2018) Fundamental Critical Care Support Course Lecture, St Paul, MN, attended 4/26/2018
- Marino (1991) ICU Book, Lea & Febiger, p. 368
- Mallemat and Swadron in Herbert (2013) EM:Rap 13(12): 11
- Roginski, Hogan and Buscher (2020) Crit Dec Emerg Med 34(6): 17-27
- Schaub, Peluso and Stull (2020) Crit Dec Emerg Med 34(9): 3-12
- Swaminathan and Mallemat in Herbert (2020) 20(7): 10-1