II. Mechanism
III. Adverse Effects
- See Protease Inhibitor for adverse effects attributed to the class
- Indirect Hyperbilirubinemia
- Rash (20%)
- Does not typically require stopping the medication
- Nephrolithiasis
- EKG Abnormalities
- PR prolongation
- Other cardiac conduction abnormalities
IV. Dosing
- Take with food
V. Drug Interactions
- Acid suppressants (Proton Pump Inhibitors, H2 Blockers)
- Proton Pump Inhibitors renders Atrazanavir ineffective and results in a high risk of developing resistance
- Atrazanavir requires acid in Stomache for absorption