II. Epidemiology: Prevalence

  1. Males: 1 in 7500
  2. Females: 1 in 50,000

III. Pathophysiology

  1. Secondary to LHRH deficiency (GnRH deficiency)
  2. Results in isolated Hypogonadotropic Hypogonadism
    1. Kallmann's Syndrome is most common cause
  3. Partial LHRH deficiency results in fertile eunuch

IV. Signs

  1. Anosmia or Hyposmia
  2. Delayed Puberty
  3. Small Testes (size correlates with LHRH deficiency)
  4. Micropenis (50% of cases)
  5. Other findings seen in Hypogonadotropic Hypogonadism
    1. Gynecomastia
    2. Undescended Testes (Cryptorchidism)

V. Associated Conditions (loosely correlated)

VI. References

  1. Wilson (1998) Williams Endocrinology, p. 1555-6

Images: Related links to external sites (from Bing)

Related Studies