Kallmann's Syndrome

Aka: Kallmann's Syndrome, Fertile Eunuch Syndrome

advertisement

II. Epidemiology: Prevalence

  1. Males: 1 in 7500
  2. Females: 1 in 50,000

III. Pathophysiology

  1. Secondary to LHRH deficiency (GnRH deficiency)
  2. Results in isolated Hypogonadotropic Hypogonadism
    1. Kallmann's Syndrome is most common cause
  3. Partial LHRH deficiency results in fertile eunuch

IV. Signs

  1. Anosmia or Hyposmia
  2. Delayed Puberty
  3. Small Testes (size correlates with LHRH deficiency)
  4. Micropenis (50% of cases)
  5. Other findings seen in Hypogonadotropic Hypogonadism
    1. Gynecomastia
    2. Undescended Testes (Cryptorchidism)

V. Associated Conditions (loosely correlated)

  1. Cleft Lip and Palate
  2. Seizure Disorder
  3. Short Metacarpals
  4. Pes cavus
  5. Sensorineural Hearing Loss
  6. Cerebellar Ataxia

VI. References

  1. Wilson (1998) Williams Endocrinology, p. 1555-6

Images: Related links to external sites (from Bing)

These images are a random sampling from a Bing search on the term "Kallmanns Syndrome." Click on the image (or right click) to open the source website in a new browser window. Search Bing for all related images

Related Studies

Related Topics in Sexual Development

advertisement