II. Epidemiology
- Toxic Multinodular Goiter is second most common cause of Hyperthyroidism in U.S. (5% of cases)
III. Risk Factors
- Diets deficient in Iodine (esp. elderly)
IV. Causes
- Simple Goiter develops into Multinodular Goiter
V. Types
- Non-Toxic Multinodular Goiter
- Toxic Multinodular Goiter (50%)
- Increase in clonogenic cells with TSH receptor mutation (somatic activating)
- Results in Thyrotoxicosis
VI. Differential Diagnosis
IX. Complications
- Toxic Multinodular Goiter (Thyrotoxicosis)
- Cardiovascular complications
- No Ophthalmopathy (Proptosis and stare)
- No Dermopathy
- Both Toxic and Non-Toxic Multinodular Goiter
- Superior Vena Cava Syndrome
- Results from thoracic outlet obstruction
- Superior Vena Cava Syndrome
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Related Studies
| Concepts | Disease or Syndrome (T047) |
| ICD9 | 242.2 |
| ICD10 | E05.2 |
| SnomedCT | 190249001, 154658002, 26389007 |
| English | Thyrotox + tox multinod goiter, Thyrotox + tox multinod goitre, Thyrotoxic - multinodul goiter, Thyrotoxic - multinodul goitre, Toxic multinodular goiter NOS, Toxic multinodular goitre NOS, toxic multinodular goiter, toxic multinodular goiter (diagnosis), parry disease, multinodular toxic goiter, Goitre;multinodular;toxic, multinodular toxic goitre, Toxic multinodular goitre (disorder), Toxic multinodular goiter NOS (disorder), Toxic multinodular goiter, Secondary thyroid hyperplasia, Thyrotoxicosis due to multinodular goiter, Thyrotoxicosis due to multinodular goitre, Thyrotoxicosis with toxic multinodular goiter, Thyrotoxicosis with toxic multinodular goitre, Toxic multinodular goitre, Toxic multinodular goiter (disorder), Parry, goiter; thyrotoxicosis, multinodular, multinodular; goiter, toxic or with hyperthyroidism, nodular; goiter, with thyrotoxicosis, struma; multinodular, toxic or with hyperthyroidism, struma; nodular, with thyrotoxicosis, struma; thyrotoxicosis, nodular, struma; toxic, multinodular, thyrotoxicosis; goiter, multinodular, thyrotoxicosis; goiter, nodular, toxic; goiter, multinodular, Goiter;multinodular;toxic, toxic multinodular goitre |
| Dutch | toxisch multinodulair struma, multinodulair; struma, toxisch of met hyperthyroïdie, nodulair; struma, met thyrotoxicose, struma; multinodulair, toxisch of met hyperthyroïdie, struma; nodulair, met thyrotoxicose, struma; thyrotoxicose, multinodulair, struma; thyrotoxicose, nodulair, struma; toxisch, multinodulair, thyrotoxicose; struma, multinodulair, thyrotoxicose; struma, nodulair, toxisch; struma, multinodulair, Thyrotoxicose met toxische multinodulaire struma |
| French | Goitre multinodulaire toxique |
| German | toxische multi-nodulaere Struma, Hyperthyreose mit toxischer mehrknotiger Struma |
| Italian | Gozzo multinodulare tossico |
| Portuguese | Bócio multinodular tóxico |
| Spanish | Bocio multinodular tóxico, bocio tóxico multinodular, SAI (trastorno), bocio tóxico multinodular, SAI, bocio multinodular tóxico (trastorno), bocio multinodular tóxico, hiperplasia tiroidea secundaria |
| Japanese | ﾁｭｳﾄﾞｸｾｲﾀｹｯｾﾂｾｲｺｳｼﾞｮｳｾﾝｼｭ, 中毒性多結節性甲状腺腫 |
| Czech | Toxická mnohouzlová struma |
| Korean | 중독성 다결절성 갑상샘종을 동반한 갑상샘중독증 |
| Hungarian | Toxikus multinodularis struma |
Ontology: Non-toxic multinodular goiter (C0271761)
| Concepts | Disease or Syndrome (T047) |
| ICD9 | 241.1 |
| ICD10 | E04.2 |
| SnomedCT | 154653006, 36241006 |
| English | Nontoxic multinodular goiter, Nontoxic multinodular goitre, nontoxic multinodular goiter (diagnosis), nontoxic multinodular goiter, Nontox multinodul goiter, Goitre;multinodular;non toxic, Non-toxic multinodular goitre (disorder), Multinodular non-toxic goiter, Non-toxic multinodular goiter, Multinodular non-toxic goitre, Non-toxic multinodular goitre, Non-toxic multinodular goiter (disorder), nontoxic; goiter, multinodular, struma; nontoxic, multinodular, Goiter;multinodular;non toxic, non toxic multinodular goiter, non toxic multinodular goitre |
| Dutch | niet-toxische multinodulaire struma, niet-toxisch multinodulair struma, niet-toxisch; struma, multinodulair, struma; niet-toxisch, multinodulair, Niet-toxische multinodulaire struma |
| French | Goitre multinodulaire non toxique |
| German | nicht-toxische multi-nodulaere Struma, Nichttoxische mehrknotige Struma |
| Italian | Gozzo multinodulare non tossico |
| Portuguese | Bócio multinodular não tóxico |
| Spanish | Bocio multinodular no tóxico, bocio multinodular no tóxico (trastorno), bocio multinodular no tóxico, bocio no tóxico multinodular |
| Japanese | 非中毒性多結節性甲状腺腫, ﾋﾁｭｳﾄﾞｸｾｲﾀｹｯｾﾂｾｲｺｳｼﾞｮｳｾﾝｼｭ |
| Czech | Netoxická mnohouzlová struma |
| Korean | 비중독성 다결절성 갑상샘종 |
| Hungarian | Nem-toxikus multinodularis struma |
Ontology: Multinodular goiter (C0342208)
| Concepts | Disease or Syndrome (T047) |
| SnomedCT | 237570007 |
| English | the thyroid had multiple nodules, Multinodular goiter, multiple nodules of thyroid, multiple nodules of thyroid (physical finding), multinodular goiter, multiple nodules thyroid, multinodular thyroid, goiters multinodular, multinodular goitre, thyroid multinodular, Multinodular goitre, Multiple thyroid nodules, Multinodular goiter (disorder), multinodular; goiter, struma; multinodular |
| Dutch | multinodulair; struma, struma; multinodulair |
| Spanish | bocio multinodular (trastorno), bocio multinodular, nódulos tiroideos múltiples |
