II. Pathophysiology
- Idiopathic destructive Thyroiditis resulting in fibrosis of Thyroid and adjacent neck
- May be associated with more generalized fibrosis
- Idiopathic Multifocal Fibrosclerosis
III. Epidemiology
- Onset age 30 to 60 years
IV. Symptoms
V. Signs
- Very firm (rock or wood-like) Thyroid swelling (Goiter)
- Hypothyroidism (30%)
VI. Labs
-
Thyroid Function Tests (T4 Free and TSH)
- Most patients are euthyroid (70%)
- Hypothyroidism (Increased Serum TSH and decreased T4 Free) in up to 30% of cases
- Antithyroid peroxidase antibodies (>60%)
-
Serum Calcium
- Hypocalcemia occurs if fibrosis affects the adjacent Parathyroid Glands
VII. Imaging
-
Radioiodine Uptake (Thyroid uptake and scan)
- Low uptake (contrast with Grave's Disease)
VIII. Diagnosis
- Thyroid biopsy
IX. Management: Tracheal or esophageal compression
- First-line
- Surgical decompression
- Other agents (no definitive treatment)
- Corticosteroids
- Mycophenolate (Cellcept)
- Methotrexate
- Tamoxifen (suppresses fibroblast proliferation)
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Related Studies
| Concepts | Disease or Syndrome (T047) |
| ICD10 | E06.5 |
| SnomedCT | 89024000, 237540002, 190298005 |
| English | THYROIDITIS CHRONIC <RIEDELS>, Reidel's thyroiditis, Riedel's thyroiditis (diagnosis), THYROIDITIS CHRONIC RIEDELS, Riedel thyroiditis, reidel struma, riedel thyroiditis, invasive fibrous thyroiditis, riedels thyroiditis, riedel's thyroiditis, Invasive thyroiditis, Ligneous thyroiditis (disorder), Ligneous thyroiditis, Riedel's thyroiditis, Invasive fibrous thyroiditis, Struma fibrosa thyroid, Woody thyroiditis, Riedel's thyroiditis (disorder), Riedel; struma, Riedel; thyroiditis, ligneous; thyroiditis, struma; Riedel, thyroiditis; Riedel, thyroiditis; ligneous, thyroiditis; woody, woody; thyroiditis |
| Dutch | invasieve thyroïditis, Riedel thyreoïditis, Reidel's thyroïditis, Riedel; struma, Riedel; thyroïditis, houtachtig; thyroïditis, lignosa; thyroïditis, struma; Riedel, thyroïditis; Riedel, thyroïditis; houtachtig, thyroïditis; lignosa |
| French | Thyroïdite de Riedel, Thyroïdite ligneuse, Thyroïdite invasive |
| German | invasive Thyreoiditis, Ligneous Thyroiditis, Riedel-Thyroiditis |
| Italian | Tiroidite invasiva, Tiroidite lignea, Tiroidite di Riedel |
| Portuguese | Tiroidite invasiva, Tiroidite de Riedel, Tiroidite lenhosa |
| Spanish | Tiroiditis invasiva, Tiroiditis leñosa, Tiroiditis de Riedel, tiroiditis de Riedel (trastorno), tiroiditis de Riedel, tiroiditis fibrosa invasiva, tiroiditis leñosa, tiroiditis por estruma fibroso |
| Japanese | 木様甲状腺炎, リーデル甲状腺炎, 侵入性甲状腺炎, ﾘｰﾃﾞﾙｺｳｼﾞｮｳｾﾝｴﾝ, ﾓｸﾖｳｺｳｼﾞｮｳｾﾝｴﾝ, ｼﾝﾆｭｳｾｲｺｳｼﾞｮｳｾﾝｴﾝ |
| Czech | Thyroiditis lignea, Riedlova tyreoiditida, Invazivní tyreoiditida |
| Hungarian | Riedel-thyreoiditis, Invasiv thyreoiditis, Thyreoiditis ligneosa |
Ontology: Fibrous autoimmune thyroiditis (C0271813)
| Concepts | Pathologic Function (T046) |
| ICD9 | 245.3 |
| ICD10 | E06.5 |
| SnomedCT | 190298005, 84362007 |
| English | Chronic fibrous thyroiditis, chronic fibrous thyroiditis, chronic fibrous thyroiditis (diagnosis), Thyroiditis fibrous chronic, Chr fibrous thyroiditis, Chronic thyroiditis, fibrous variant, Fibrous autoimmune thyroiditis, Hashimoto thyroiditis, fibrous variant, Noninvasive fibrous thyroiditis, Fibrous autoimmune thyroiditis (disorder), chronic; thyroiditis, fibrous, thyroiditis; chronic, fibrous |
| Italian | Tiroidite fibrosa cronica |
| Dutch | chronische fibreuze thyreoïditis, chronisch; thyroïditis, fibreus, thyroïditis; chronisch, fibreus, thyreoïditis fibreus chronisch |
| German | chronische fibroese Thyreoiditis, Thyreoiditis fibroes chronisch |
| Japanese | 慢性線維性甲状腺炎, ﾏﾝｾｲｾﾝｲｾｲｺｳｼﾞｮｳｾﾝｴﾝ |
| Czech | Chronický fibrózní zánět štítné žlázy, Chronická fibrózní tyreoiditida |
| Hungarian | Chronikus fibrosus thyreoiditis |
| Spanish | tiroiditis crónica, variante fibrosa, tiroiditis de Hashimoto, variante fibrosa (trastorno), tiroiditis de Hashimoto, variante fibrosa, tiroiditis fibrosa autoinmune, Tiroiditis fibrosa crónica |
| Portuguese | Tiroidite fibrosa crónica |
| French | Thyroïdite fibreuse chronique |
