II. Epidemiology
- Sensitivity: 100% of Myocardial Infarctions
-
Specificity: Low (36% have Unstable Angina)
- See Troponin for false possible causes
III. Labs: Timing Following Acute Myocardial Infarction
- Serum levels increase within 4-8 hours of MI onset
- Serum levels peak at 12 to 48 hours
- Serum levels are elevated for 4-10 days after MI
IV. Advantages
- More specific than Troponin T
- Not falsely elevated in Chronic Renal Failure
V. Technique: ED Acute Coronary Syndrome evaluation
- Obtain 2 Troponin values 6 hours apart
VI. Interpretation
- Level >1.0 to 1.2 suggestive of Myocardial Infarction
- Two negative values 3-6 hours apart
- Predicts low likelihood of Acute Coronary Syndrome
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Related Studies
| Definition (NCI) | Troponin I, troponin T, and troponin C are the three closely associated subunits of the troponin complex of thin filaments in muscle. The complex serves as a calcium-sensitive switch that regulates muscle contraction. In the absence of calcium, Troponin I binds actin, inhibits actomyosin ATPase activity, and inhibits F-actin-myosin interactions. The troponin I gene family comprises three isoforms: skeletal TNI-fast, skeletal TNI-slow, and TNI-cardiac. (from OMIM 191044, 191043, 191042 and NCI) |
| Definition (MSH) | One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions. |
| Concepts | Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116) |
| MSH | D019210 |
| SnomedCT | 102683006 |
| English | Troponin I, Troponin-I, inhibitory troponin I, TnI, Troponin I [Chemical/Ingredient], tni, troponin-i, troponin i, Inhibitory troponin subunit, Troponin I (substance) |
| Swedish | Troponin I |
| Czech | troponin I |
| Finnish | Troponiini I |
| Russian | TROPONIN I, ТРОПОНИН I |
| Japanese | トロポニンI |
| Polish | Troponina I |
| Croatian | Troponin I |
| Spanish | subunidad de troponina inhibitoria, troponina I (sustancia), troponina I, Troponina I |
| French | Troponine I |
| German | Troponin I |
| Italian | Troponina I |
| Portuguese | Troponina I |
Ontology: Troponin I measurement (C0920210)
| Definition (NCI) | The determination of the amount of troponin I present in a blood sample. |
| Definition (NCI_CDISC) | A measurement of the actin binding troponin in a biological specimen. |
| Concepts | Laboratory Procedure (T059) |
| SnomedCT | 121870001 |
| English | Troponin I, Troponin I Measurement, troponin i level test, troponin i test, Troponin I measurement, TROPONI, Troponin I measurement (procedure) |
| Italian | Troponina I |
| Japanese | トロポニンＩ, ﾄﾛﾎﾟﾆﾝI |
| Czech | Troponin I |
| Hungarian | Troponin I |
| Spanish | medición de troponina I (procedimiento), medición de troponina I, Troponina I |
| Portuguese | Tropoinina I |
| Dutch | troponine-I |
| French | Troponine I |
| German | Troponin I |
