II. Epidemiology
- Test Sensitivity: 94% of Myocardial Infarctions
-
Test Specificity: Low (22% have Unstable Angina)
- See Troponin for false possible causes
III. Labs: Timing Following Acute Myocardial Infarction
- Serum levels increase within 4-8 hours of MI onset
- Serum levels peak at 12 to 48 hours
- Serum levels are elevated for 4-10 days after MI
IV. Advantages
- Highly sensitive for detecting Myocardial Infarction
- Level may also help to risk stratify afterward
- Qualitative test run in 10 minutes
V. Disadvantage
- Less specific than Troponin I
- Elevated in Unstable Angina
- Elevated in Chronic Renal Failure
- Levels stay elevated for days
- Unable to time acute coronary event
Images: Related links to external sites (from Bing)
Related Studies
| Definition (NCI) | Troponin I, troponin T, and troponin C are the three closely associated subunits of the troponin complex of thin filaments in muscle. The complex serves as a calcium-sensitive switch that regulates muscle contraction. Because it is not normally found in blood, cardiac troponin-T in serum is a sensitive indicator of myocardial cell injury. |
| Definition (MSH) | One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY. |
| Concepts | Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116) |
| MSH | D020107 |
| SnomedCT | 102682001 |
| English | Troponin T, tropomyosin binding protein troponin T, TnT, T, Troponin, Troponin-T, Tropomyosin-binding troponin, Troponin T [Chemical/Ingredient], troponin-t, troponin t, t troponin, tnt, tnts, Tropomyosin-binding troponin subunit, Troponin T (substance) |
| Swedish | Troponin T |
| Czech | troponin T |
| Finnish | Troponiini T |
| Russian | TROPONIN T, ТРОПОНИН T |
| Japanese | トロポニンT |
| Polish | Troponina T |
| Spanish | subunidad de troponina fijadora de tropomiosina, troponina T (sustancia), troponina T, Troponina T |
| French | Troponine T |
| German | Troponin T |
| Italian | Troponina T |
| Portuguese | Troponina T |
Ontology: Troponin T Assay (C1141947)
| Definition (NCI_CDISC) | A measurement of the tropomyosin binding troponin in a biological specimen. |
| Definition (NCI) | The determination of the amount of troponin T present in a blood sample. |
| Concepts | Laboratory Procedure (T059) |
| SnomedCT | 121871002 |
| Italian | Troponina T |
| English | Troponin T, Troponin T Measurement, troponin t, t troponin, TROPONT, Troponin T Assay, Troponin T measurement (procedure), Troponin T measurement |
| Japanese | トロポニンＴ, ﾄﾛﾎﾟﾆﾝT |
| Czech | Troponin T |
| Hungarian | Troponin T |
| Spanish | medición de troponina T (procedimiento), medición de troponina T, Troponina T |
| Portuguese | Troponina T |
| Dutch | troponine T |
| French | Troponine T |
| German | Troponin T |
