II. Epidemiology

  1. Test Sensitivity: 94% of Myocardial Infarctions
  2. Test Specificity: Low (22% have Unstable Angina)
    1. See Troponin for false possible causes

III. Labs: Timing Following Acute Myocardial Infarction

  1. Serum levels increase within 4-8 hours of MI onset
  2. Serum levels peak at 12 to 48 hours
  3. Serum levels are elevated for 4-10 days after MI

IV. Advantages

  1. Highly sensitive for detecting Myocardial Infarction
  2. Level may also help to risk stratify afterward
  3. Qualitative test run in 10 minutes

V. Disadvantage

  1. Less specific than Troponin I
    1. Elevated in Unstable Angina
    2. Elevated in Chronic Renal Failure
  2. Levels stay elevated for days
    1. Unable to time acute coronary event

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Related Studies

Ontology: Troponin T (C0077404)

Definition (NCI) Troponin I, troponin T, and troponin C are the three closely associated subunits of the troponin complex of thin filaments in muscle. The complex serves as a calcium-sensitive switch that regulates muscle contraction. Because it is not normally found in blood, cardiac troponin-T in serum is a sensitive indicator of myocardial cell injury.
Definition (MSH) One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
Concepts Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116)
MSH D020107
SnomedCT 102682001
English Troponin T, tropomyosin binding protein troponin T, TnT, T, Troponin, Troponin-T, Tropomyosin-binding troponin, Troponin T [Chemical/Ingredient], troponin-t, troponin t, t troponin, tnt, tnts, Tropomyosin-binding troponin subunit, Troponin T (substance)
Swedish Troponin T
Czech troponin T
Finnish Troponiini T
Japanese トロポニンT
Polish Troponina T
Spanish subunidad de troponina fijadora de tropomiosina, troponina T (sustancia), troponina T, Troponina T
French Troponine T
German Troponin T
Italian Troponina T
Portuguese Troponina T

Ontology: Troponin T Assay (C1141947)

Definition (NCI_CDISC) A measurement of the tropomyosin binding troponin in a biological specimen.
Definition (NCI) The determination of the amount of troponin T present in a blood sample.
Concepts Laboratory Procedure (T059)
SnomedCT 121871002
Italian Troponina T
English Troponin T, Troponin T Measurement, troponin t, t troponin, TROPONT, Troponin T Assay, Troponin T measurement (procedure), Troponin T measurement
Japanese トロポニンT, トロポニンT
Czech Troponin T
Hungarian Troponin T
Spanish medición de troponina T (procedimiento), medición de troponina T, Troponina T
Portuguese Troponina T
Dutch troponine T
French Troponine T
German Troponin T