II. Indications
- Consider in patients at higher risk of ASCVD, to further risk stratify
III. Physiology
- Lipoprotein A is structurally similar to LDL Cholesterol, but with an added group
- Added group is Apoprotein A (apolipoprotein A) linked by disulfide bonds to Apolipoprotein B-100
- Increased Lipoprotein A plasma levels are associated with an increased risk of ASCVD
IV. Interpretation
- Lipoprotein A >50 mg/dl
- Associated with an increased Cardiovascular Risk and stroke
- Lipoprotein A >70 mg/dl
- Associated with high Cardiovascular Risk
V. Efficacy
- Moderate association with ASCVD risk, with generally stable levels after age 5 years, and inexpensive to test
VI. Management
- Lipoprotein A is not lowered by typical Hyperlipidemia Management (e.g. lifestyle, Statins)
- Methods that do lower Lipoprotein A levels (but not FDA approved, and no established protocols)
- PCSK9 Inhibitors
- Lipoprotein Apheresis
VII. References
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| Definition (MSH) | A lipoprotein that resembles the LOW-DENSITY LIPOPROTEINS but with an extra protein moiety, APOPROTEIN (A) also known as APOLIPOPROTEIN (A), linked to APOLIPOPROTEIN B-100 on the LDL by one or two disulfide bonds. High plasma level of lipoprotein (a) is associated with increased risk of atherosclerotic cardiovascular disease. |
| Concepts | Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116) |
| MSH | D017270 |
| SnomedCT | 116661000 |
| LNC | LP14886-3, MTHU002110 |
| English | Lipoprotein (a), Lipoprotein Lp(a), Lipoprotein(a), Lipoprotein a, LIPOPROTEIN(a), LIPOPROTEIN A, Lipoprotein(a) [Chemical/Ingredient], lipoprotein little a, a lipoprotein, a lp, lipoprotein a, lp a, Lipoprotein (little a), Lipoprotein A, Lp(a), Lipoprotein (a) (substance) |
| French | Lipoprotéine (a), Lipoprotéine(a), Lipoprotéine Lp(a), Lp(a) |
| Swedish | Lipoprotein(a) |
| Czech | lipoprotein(a), Lp(a) |
| Finnish | Lipoproteiini(a) |
| Russian | LIPOPROTEIN A, ЛИПОПРОТЕИН A |
| Japanese | リポ蛋白質(a), リポ蛋白質A, リポプロテイン(a), リポタンパク質(a) |
| German | LIPOPROTEIN A, LP A, Lipoprotein(a), Lp(a) |
| Croatian | LIPOPROTEIN (A), LIPOPROTEIN(A) |
| Polish | Lipoproteina A |
| Spanish | Lp (a), lipoproteína (a) (sustancia), lipoproteína (a), Lipoproteína(a) |
| Italian | Lipoproteina(a) |
| Portuguese | Lipoproteína(a) |
