II. Pathophysiology

  1. Maternal Rh Sensitization
    1. Maternal anti-Rh Antibodies are present in newborn plasma
  2. Results in fetal Hemolytic Anemia (Alloimmune Hemolytic Anemia)
    1. Increased Unconjugated Hyperbilirubinemia
    2. Compensating Erythropoiesis
    3. Hepatosplenomegaly
      1. Red Blood Cell production and destruction
    4. Placenta enlarged
  3. Additional Risk Factors
    1. G6PD Deficiency (highest risk for Kernicterus)

III. Labs

  1. Direct Antibody Test (Direct Coombs test) positive

V. Complications

  1. Fetal hydrops
  2. Hemolytic Anemia
  3. Congenital Anemia (Mild Hemolysis)
  4. Icterus Gravis (Severe Hemolysis)
  5. Kernicterus

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Ontology: Erythroblastosis, Fetal (C0014761)

Definition (NCI) A disorder of the fetus or newborn that occurs when fetal cells that are coated with IgG alloantibodies from the mother attack antigens inherited from the father. Severity can range from absence of symptoms to death.
Definition (CSP) hemolytic anemia of the fetus or newborn caused by transplacental transmission of maternally formed antibody, usually secondary to an incompatibility between the blood groups of mother and offspring.
Definition (MSH) A condition characterized by the abnormal presence of ERYTHROBLASTS in the circulation of the FETUS or NEWBORNS. It is a disorder due to BLOOD GROUP INCOMPATIBILITY, such as the maternal alloimmunization by fetal antigen RH FACTORS leading to HEMOLYSIS of ERYTHROCYTES, hemolytic anemia (ANEMIA, HEMOLYTIC), general edema (HYDROPS FETALIS), and SEVERE JAUNDICE IN NEWBORN.
Concepts Disease or Syndrome (T047)
MSH D004899
ICD9 773.2, 773
ICD10 P55 , P55.9
SnomedCT 123307003, 206429000, 111468003, 206436004, 25121006, 276577009, 206430005, 268878003, 206431009, 157130001, 387705004, 33130007
English Erythroblastoses, Fetal, Fetal Erythroblastoses, Fetal Erythroblastosis, Hemolytic Disease of Newborn, Newborn Hemolytic Disease, Newborn Hemolytic Diseases, Hemolytic disease of fetus or newborn, due to isoimmunization, Hemolytic disease due to other and unspecified isoimmunization of fetus or newborn, HDN - Haemol diseas of newborn, Haemolytic disease of fetus and newborn due to isoimmunisation, Haemolytic disease of fetus and newborn due to isoimmunisation NOS, Haemolytic disease of fetus/newborn due isoimmunisation NOS, Haemolytic disease of fetus/newborn due to isoimmunisation, Haemolytic disease of newborn, Hemolytic dis.of newborn NOS, Hemolytic disease of fetus and newborn due to isoimmunization, Hemolytic disease of fetus and newborn due to isoimmunization NOS, Hemolytic disease of fetus/newborn due isoimmunization NOS, Hemolytic disease of fetus/newborn due to isoimmunization, Haemolytic dis.- isoimmun.NOS, Haemolytic disease due to isoimmunisation NOS, Hemolytic dis.- isoimmun.NOS, Hemolytic disease due to isoimmunization NOS, HEMOLYTIC DIS NEWBORN, fetal hemolysis due to isoimmunization, fetal hemolysis due to isoimmunization (diagnosis), Haemolytic disease of fetus and newborn due to isoimmunisation (disorder), fetal or neonatal hemolysis due to isoimmunization, fetal or neonatal hemolysis due to isoimmunization (diagnosis), Haemolytic disease of fetus or newborn, due to isoimmunization, Haemolytic disease due to other and unspecified isoimmunization of fetus or newborn, Haemolytic disease of fetus OR newborn due to isoimmunisation, NB hemolyt dis-isoim NEC, Hemolytic disease of newborn, unspecified, Erythroblastosis, Fetal [Disease/Finding], disease fetus hemolytic, disease haemolytic newborn, disease haemolytic newborns, fetal erythroblastosis, hemolytic disease of the newborn, erythroblastosis foetalis, hemolytic disease newborn, hemolytic disease of newborn, Disease;haemolytic;newborn, disease hemolytic newborns, erythroblastosis fetalis, disease hemolytic newborn, disease hemolytic of newborn, diseases hemolytic newborn, icterus gravis neonatorum, haemolytic disease newborn, Erythroblastosis, Fetal, Hemolytic disease of fetus or newborn due to other and unspecified isoimmunization, hemolytic disease of newborn (diagnosis), Hemolytic disease of newborn, HDFN, Erythroblastosis neonatorum, Hemolytic disease of fetus and newborn due to isoimmunization NOS (disorder), Erythroblastosis fetalis (disorder), Haemolytic disease due to other and unspecified isoimmunisation of foetus or newborn, Haemolytic disease of foetus or newborn, due to isoimmunisation, Hemolytic disease of fetus and newborn due to isoimmunization (disorder), Haemolytic disease of foetus and newborn due to isoimmunisation NOS, Hemolytic disease due to isoimmunization NOS (disorder), Haemolytic disease of foetus and newborn due to isoimmunisation, Neonatal isoerythrolysis, Hemolytic Disease of the Fetus or Newborn, Hemolytic Disease of the Newborn, Erythroblastosis fetalis, Alloimmune hemolytic disease of newborn, EF - Erythroblastosis fetalis, HDN - Haemolytic disease of the newborn, HDN - Hemolytic disease of the newborn, Haemolytic disease of the newborn, Hemolytic disease of the newborn, Alloimmune haemolytic disease of newborn, Isoimmunisation of newborn, Isoimmunization of newborn, Erythroblastosis foetalis, EF - Erythroblastosis foetalis, Haemolytic disease of foetus OR newborn due to isoimmunisation, Hemolytic disease of fetus OR newborn due to isoimmunization (disorder), Hemolytic disease of fetus OR newborn due to isoimmunization, Erythroblastosis fetalis, NOS, Erythroblastosis neonatorum, NOS, Hemolytic disease of fetus or newborn due to isoimmunization, NOS, Erythroblastosis foetalis, NOS, Haemolytic disease of foetus or newborn due to isoimmunization, NOS, Erythroblastosis fetalis -RETIRED-, Haemolytic disease of fetus or newborn due to isoimmunisation, NOS, Hemolytic disease of fetus NOS, Hemolytic disease of newborn NOS, Erythroblastosis fetalis NOS, Erythroblastosis neonatorum NOS, Erythroblastosis Fetalis, Erythroblastosis Fetali, Fetali, Erythroblastosis, Fetalis, Erythroblastosis, Disease;hemolytic;newborn, haemolytic disease of a newborn, hemolytic disease of a newborn
Dutch hemolytische aandoening van foetus of pasgeborene door iso-immunisatie, hemolytische ziekte t.g.v. andere, niet-gespecificeerde iso-immunisatie van foetus of pasgeborene, hemolytiche aandoening door andere en niet-gespecificeerde iso-immunisatie van foetus of pasgeborene, hemolytische aandoening van foetus of pasgeborene, ten gevolge van iso-immunisatie, hemolytiche aandoening van foetus of pasgeborene door iso-immunisatie, hemolytische aandoening door andere en niet-gesp iso-immunisatie van foetus of pasgeborene, erythroblastosis foetalis, Erythroblastosis foetalis, Hemolytische anemie van de pasgeborene, Icterus gravis neonatorum, Morbus haemolyticus neonatorum
French Maladie hémolytique due à une autre isoimmunisation non précisée du foetus ou du nouveau-né, Maladie hémolytique due à une autre iso-immunisation non préc du foetus ou du nouveau-né, Maladie hémolytique due à une autre iso-immunisation non précisée du foetus ou du nouveau-né, Maladie hémolytique du foetus ou du nouveau-né due à une isoimmunisation, Maladie hémolytique du foetus ou du nouveau-né, due à l'isoimmunisation, Maladie hémolytique du foetus ou du nouveau-né, due à l'iso-immunisation, Maladie hémolytique des nouveau-nés, Maladie hémolytique néonatale, MHNN, Erythroblastose foetale, Érythroblastose foetale, Maladie hémolytique du nouveau-né
German haemolytische Krankheit infolg sonstig u. unspezifisch Immunisierung des Fetus oder Neugeborenen, haemolytische Krankheit infolg sonstig u. unspezif Isoimmunisierung des Feten od Neugeborenen, haemolytische Krankheit des Feten oder Neugeborenen infolge Isoimmunisierung, Erythroblastose fetal, Erythroblastose, fetale, Hämolytische Erkrankung des Neugeborenen, Erythroblastosis fetalis
Italian Malattia emolitica del feto o del neonato dovuta ad altra non specificata isoimmunizzazione, Malattia emolitica da altra e non specificata isoimmunizzazione fetale o neonatale, Malattia emolitica del feto o del neonato dovuta a isoimmunizzazione, Malattia emolitica fetale o neonatale da isoimmunizzazione, Malattia emolitica del neonato, Eritroblastosi fetale
Portuguese Doença hemolítica por outra isoimunização e NE do feto ou recém-nascido, Doença hemolítica por isoimunização do feto ou recém-nascido, Eritroblastose fetal, Doença Hemolítica do Recém-Nascido, Eritroblastose Fetal
Spanish Enfermedad hemolítica por otras isoinmunizaciones y las no especif del feto o del recién nacido, Enfermedad hemolítica del feto o del recién nacido, por isoinmunización, Enfermedad hemolítica del feto o del recién nacido por isoinmunización, eritroblastosis fetal - RETIRADO - (concepto no activo), eritroblastosis fetal, enfermedad hemolítica fetal o neonatal por isoinmunización, isoinmunización del recién nacido, isoeritrólisis neonatal, enfermedad hemolítica aloinmune del recién nacido, enfermedad hemolítica del feto y del recién nacido por isoinmunización, SAI (trastorno), enfermedad hemolítica autoinmunitaria del recién nacido, eritroblastosis fetalis, eritroblastosis fetal, no especificada, enfermedad hemolítica por isoinmunización, SAI, enfermedad hemolítica por isoinmunización, SAI (trastorno), anemia hemolítica del recién nacido, no especificada, eritroblastosis fetal - RETIRADO -, enfermedad hemolítica del feto y del recién nacido por isoinmunización, SAI, enfermedad hemolítica aloinmune del feto O recién nacido, enfermedad hemolítica del recién nacido, eritroblastosis neonatal, enfermedad hemolítica del feto O recién nacido por isoinmunización (trastorno), enfermedad hemolítica del feto O recién nacido por isoinmunización, Eritroblastosis fetal, Enfermedad Hemolítica del Recién Nacido, Eritroblastosis Fetal
Japanese 胎児あるいは新生児のその他および詳細不明の同種免疫による溶血性疾患, 胎児・新生児の同種免疫による溶血性疾患, タイジアルイハシンセイジノソノタオヨビショウサイフメイノドウシュメンエキニヨルヨウケツセイシッカン, タイジシンセイジノドウシュメンエキニヨルヨウケツセイシッカン, タイジセキガキュウショウ, 黄疸-新生児重症, 赤芽球症-胎児, 新生児溶血性疾患, 新生児重症黄疸, 胎児赤芽球症
Swedish Hemolytisk sjukdom hos nyfödda
Finnish Vastasyntyneen hemolyyttinen tauti
Russian GEMOLITICHESKAIA BOLEZN' NOVOROZHDENNYKH, ERITROBLASTOZ PLODA, ANEMIIA GEMOLITICHESKAIA NOVOROZHDENNYKH, АНЕМИЯ ГЕМОЛИТИЧЕСКАЯ НОВОРОЖДЕННЫХ, ГЕМОЛИТИЧЕСКАЯ БОЛЕЗНЬ НОВОРОЖДЕННЫХ, ЭРИТРОБЛАСТОЗ ПЛОДА
Czech Hemolytické onemocnění plodu nebo novorozence při jiné a blíže neurčené izoimunizaci, Hemolytické onemocnění plodu nebo novorozence při jiné a nespecifikované izoimunizaci, Fetální erytroblastóza, Hemolytické onemocnění plodu nebo novorozence způsobené izoimunizací, Hemolytické onemocnění fetu nebo novorozence způsobené izoimunizací, Erythroblastosis fetalis, erytroblastóza fetální, hemolytická nemoc novorozence, fetální erytroblastóza, hemolytické onemocnění novorozence, hemolytická nemoc plodu
Croatian FETALNA ERITROBLASTOZA
Polish Erytroblastoza płodu, Choroba hemolityczna noworodka, Choroba hemolityczna noworodków
Hungarian foetus vagy újszülött haemolytikus betegsége, isoimmunisatio okozta, haemolytikus betegség a foetus vagy az újszülött egyéb és meghatározatlan isoimmunisatiója miatt, A foetus vagy újszülött haemolyticus betegség egyébe és meghatározatlan isoimmunisatiója, magzat vagy újszülött haemolyticus betegsége, isoimmunisatio okozta, Foetalis erythroblastosis, haemolytikus betegség a magzat vagy újszülött egyéb és meghatározatlan isoimmunisatiója miatt, Magzati erythroblastosis, magzat vagy újszülött haemolytikus betegsége, isoimmunisatio okozta
Norwegian Hemolytisk sykdom hos nyfødt, Føtal erytroblastose, Erytroblastose hos foster, Erythroblastosis foetalis, Hemolytisk sykdom hos foster