III. Definition
- Inequality between pupil diameters
IV. Differential Diagnosis: General
- Congenital (normal variant in 20% of population)
- Tabes Dorsalis
- Trigeminal Neuralgia
- Carotid aneurysm
- Aortic aneurysm
- Unilateral Intracranial Mass
- Glaucoma
- Adie's Pupils
- Amblyopia
- Horner Syndrome
- Third nerve palsy (or parasympathetic abnormality)
V. Findings: Miosis (Pupil Constriction) of one, but not the other
- Iritis
- Cervical sympathetic paralysis
- Miotic drug (e.g. Pilocarpine)
VI. Findings: Mydriasis (pupil dilatation) of one, but not the other
- Mydriatic drug (e.g. Atropine)
- Cranial Nerve III paralysis
- Acute Glaucoma
- Brainstem Herniation (non-reactive dilated pupil in comatose patient)