II. Pathophysiology

  1. Autoimmune skin disorder
  2. Associated with HLA-DR3, and HLA-DR4

III. Associated conditions

IV. Signs

  1. Vesicles and bullae form on Abdomen, extremities

V. Management

  1. Increased antepartum observation
  2. Oral Antihistamines
  3. Topical Corticosteroids
  4. Systemic Corticosteroids in severe cases

VI. Complications

  1. Preterm delivery
  2. Small for Gestational Age infant

VII. Course

  1. Onset in second-half of pregnancy
  2. Improves in late pregnancy
  3. May be exacerbated in early Postpartum Period
  4. May recur in future pregnancies

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