II. Causes

  1. Untreated Acute Thiamine Deficiency (e.g. Alcoholism)
  2. See Acute Thiamine Deficiency for a full list of causes

III. Pathophysiology

  1. Follows Wernicke's Encephalopathy
  2. Lesions develop in mammillary bodies and Thalamus

IV. Signs

  1. Life-long neurologic Impairment with learning difficulties
  2. Severe Short Term Memory loss
  3. Intact Immediate Memory
  4. Confabulation

V. Management

VI. Prognosis

  1. Life-long Impairment
  2. Improvement in 75% of patients with treatment

VII. References

  1. Rendon et al. (2017) Crit Dec Emerg Med 31(6): 15-21

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