II. Epidemiology

  1. Rare Encephalitis cause in Northeastern and North Central States

III. Pathophysiology

  1. Tickborne Illness via Woodchuck Tick or Groundhog Tick (Ixodes cookei, I. marxi or I. Scapularis)

IV. Findings

  1. Presentations range from asymptomatic to severe neurologic Impairment

V. Labs

  1. Antibody to Powassan Virus (serum, CSF)

VI. Differential Diagnosis

VII. Management

  1. No known effective treatment
  2. Supportive care

VIII. Prognosis

  1. Cognitive Impairment in >50% of survivors, and 10-15% mortality

IX. Resources

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