II. Pathophysiology

  1. Mosquito-borne infection with Flavivirus
  2. Endemic regions
    1. Rural and periurban Southeast Asia and Western Pacific

III. Signs: Severe Disease (occurs in 1 of 250 infections)

IV. Diagnosis

  1. Japanese Encephalitis Serology
  2. Japanese Encephalitis Cerebrospinal fluid testing

VI. Prognosis: Severe Disease

  1. Severe disease occurs in 1 in 250 infections
  2. Severe disease mortality: 30%
  3. Severe disease permanent neuropsychological effects: 30%

VII. Prevention

  1. Japanese Encephalitis Vaccination

VIII. References

  1. Black, Martin, DeVos (2018) Crit Dec Emerg Med 32(8): 3-12

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Ontology: Japanese encephalitis virus (C0014047)

Definition (MSH) A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE), which is the etiological agent of Japanese encephalitis found in Asia, southeast Asia, and the Indian subcontinent.
Definition (CSP) species of flavivirus, one of the Japanese encephalitis virus group, which is the etiological agent of Japanese encephalitis found in Asia, southeast Asia, and the Indian subcontinent; infects man, birds, pigs and horses; probably transmitted by mosquitos.
Concepts Virus (T005)
MSH D004664
SnomedCT 87099007, 243603004
LNC LP17702-9
English Encephalitis Virus, Japanese, Japanese Encephalitis Virus, Virus, Japanese Encephalitis, Japanese enceph virus subgroup, VIRUS JAPANESE ENCEPH, ENCEPH VIRUS JAPANESE, JAPANESE ENCEPH VIRUS, JAPANESE B ENCEPH VIRUS, Japanese B virus encephalitis, Japanese B Encephalitis Virus, JAPANESE ENCEPHALITIS VIRUS, Japanese encephalitis (JE) virus, Japanese encephalitis virus JE, Japanese encephalitis virus JEV, Japanese B encephalitis virus, Japanese encephalitis virus (organism), Japanese B encephalitis virus (organism), Japanese encephalitis virus
Dutch Japanse B-virusencefalitis, Encefalitisvirus, Japanse-, Japanse-encefalitisvirus, Virus, Japanse-encefalitis-
French Encéphalite virale japonaise B, Virus de l'encéphalite japonaise (espèce), Japanese encephalitis virus, Japanese B encephalitis virus, Virus de l'encéphalite japonaise de type B
German Japan-B-Virusenzephalitis, Enzephalitisvirus, japanisches, Japanisches Enzephalitisvirus
Italian Encefalite virale B giapponese, Virus dell'encefalite B giapponese, Virus dell'encefalite giapponese
Portuguese Encefalite por vírus japonês B, Vírus da Encefalite Japonesa (Espécie)
Spanish Encefalitis vírica japonesa B, virus de la encefalitis japonesa (organismo), virus de la encefalitis japonesa, virus de la encefalitis B japonesa (organismo), virus de la encefalitis B japonesa, Virus de la Encefalitis Japonesa (Especie)
Japanese 日本脳炎B型ウイルス脳炎, ニホンノウエンBガタウイルスノウエン, 日本脳炎ウイルス, 脳炎ウイルス-日本
Swedish Encefalitvirus, japansk
Czech virus japonské encefalitidy, Japonská B encefalitida virového původu
Finnish Japanin aivotulehdusvirus
Russian ENTSEFALITA IAPONSKOGO VIRUS, ENTSEFALIT IAPONSKII, VIRUS, ENTSEFALIT OSENNII, VIRUS, ЭНЦЕФАЛИТА ЯПОНСКОГО ВИРУС, ЭНЦЕФАЛИТ ОСЕННИЙ, ВИРУС, ЭНЦЕФАЛИТ ЯПОНСКИЙ, ВИРУС
Polish Wirus zapalenia mózgu japońskiego
Hungarian Japán B vírus encephalitis

Ontology: Japanese Encephalitis (C0014057)

Definition (NCI) Viral encephalitis caused by the mosquito-born Japanese encephalitis virus. Signs and symptoms include an initial period of fever, headaches, and malaise, followed by neck rigidity, hemiparesis, and convulsions. It may lead to coma.
Definition (MSH) A mosquito-borne encephalitis caused by the Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE) occurring throughout Eastern Asia and Australia. The majority of infections occur in children and are subclinical or have features limited to transient fever and gastrointestinal symptoms. Inflammation of the brain, spinal cord, and meninges may occur and lead to transient or permanent neurologic deficits (including a POLIOMYELITIS-like presentation); SEIZURES; COMA; and death. (From Adams et al., Principles of Neurology, 6th ed, p751; Lancet 1998 Apr 11;351(9109):1094-7)
Concepts Disease or Syndrome (T047)
MSH D004672
ICD9 062.0
ICD10 A83.0
SnomedCT 266194002, 154345006, 52947006
English Encephalitis, Japanese B, Japanese B Encephalitis, Encephalitis, Japanese, JAPANESE B VIRAL ENCEPH, JAPANESE ENCEPH, ENCEPH JAPANESE, ENCEPH JAPANESE B, VIRAL ENCEPH JAPANESE B, JAPANESE B ENCEPH, Japanese encephalitis (diagnosis), Encephalitis Japanese B, Japanese B viral encephalitis, Japanese B Viral Encephalitis, Viral Encephalitis, Japanese B, Encephalitis, Japanese [Disease/Finding], encephalitis Japanese, Japanese b encephalitis, Japanese B encephalitis, Japanese encephalitis, Japanese encephalitis virus disease, JBE - Japanese B encephalitis, JE - Japanese encephalitis, Japanese encephalitis virus disease (disorder), autumnal encephalitis; Russian, autumnal; Russian autumnal encephalitis, Japanese; encephalitis, Russian; autumnal encephalitis, encephalitis; Japanese, encephalitis; Russian, autumnal, Japanese Encephalitis
Dutch Japanse B-virusencefalitis, Japans; encefalitis, Russisch; herfstencefalitis, encefalitis; Japans, encefalitis; Russisch, herfst, herfst; Russische herfstencefalitis, herfstencefalitis; Russische, Japapnse (B-type) encefalitis, Encefalitis, Japanse, Equine encefalitis, Japanse B-encefalitis, Japanse encefalitis
German japanische Enzephalitis, Japan-B-Enzephalitis, virale Japan-B-Enzephalitis, Encephalitis japonica B, Enzephalitis, japanische B, Enzephalitis, japanische, Japanische Enzephalitis
Italian Encefalite B giapponese, Encefalite virale B giapponese, Encefalite virale giapponese B, Encefalite giapponese B, Encefalite giapponese
Portuguese Encefalite japonesa B, Encefalite por vírus japonês B, Encefalite japonesa, Encefalite a vírus japonês B, Encefalite Japonesa B, Encefalite Japonesa
Spanish Encefalitis japonesa, Encefalitis vírica japonesa B, encefalitis japónica, encefalitis rusa otoñal, enfermedad virósica de la encefalitis japonesa, enfermedad virósica de la encefalitis japonesa (trastorno), enfermedad por virus de la encefalitis japonesa, enfermedad viral de la encefalitis japonesa, enfermedad por virus de la encefalitis japonesa (trastorno), encefalitis japonesa B, Encefalitis japonesa B, Encefalitis Japonesa B, Encefalitis Japonesa
Japanese 日本脳炎B型, 日本脳炎B型ウイルス脳炎, ニホンノウエンBガタ, ニホンノウエンBガタウイルスノウエン, ニホンノウエン, 日本脳炎, 日本B型脳炎, 脳炎-日本, 日本脳炎-B型, 脳炎-日本B型
Swedish Hjärninflammation, japansk
Czech encefalitida japonská B, Japonská encefalitida B, Japonská encefalitida B virového původu, Japonská encefalitida, japonská encefalitida, encefalitida japonská
Finnish Japanin aivotulehdus
Russian ENTSEFALIT IAPONSKII B, IAPONSKII ENTSEFALIT, IAPONSKII ENTSEFALIT B, ENTSEFALIT IAPONSKII, ЭНЦЕФАЛИТ ЯПОНСКИЙ B, ЭНЦЕФАЛИТ ЯПОНСКИЙ, ЯПОНСКИЙ ЭНЦЕФАЛИТ B, ЯПОНСКИЙ ЭНЦЕФАЛИТ
Korean 일본 뇌염
Polish Zapalenie mózgu japońskie, Zapalenie mózgu japońskie B
Hungarian Japán B vírusos encephalitis, Japán encephalitis, Japán B encephalitis, japán B encephalitis
Norwegian Japansk encefalitt, Japansk hjernebetennelse, Encefalitt, Japansk
French Encéphalite japonaise de type B, Encéphalite japonaise, Encéphalite japonaise B