II. Definitions

  1. Pulmonary Bleb
    1. Small (<1-2 cm), thin walled (<1 mm) air containing spaces within the lung
  2. Pulmonary Bullae
    1. Larger (>1-2 cm) air containing spaces within the lung
    2. A Pulmonary Bulla may be a coalescence of Pulmonary Blebs

III. Pathophysiology

  1. Blebs and Bullae form as a result of subpleural alveolar rupture

IV. Risk Factors

  1. Tobacco Abuse
  2. Thin Patient
  3. COPD

V. Differential Diagnosis

  1. Pneumatocele (post-Pneumonia)
  2. Pneumothorax
  3. Cystic Bronchiectasis
  4. Cavitary Lung Disease
  5. Cystic Lung Disease
    1. Lymphangioleiomyomatosis (LAM)
    2. Pulmonary Langerhans Cell Histiocytosis (PLCH)
    3. Birt-Hogg-Dube Syndrome (BHD)
    4. Lymphoid Interstitial Pneumonia (LIP)

VI. Complications

  1. Pneumothorax
  2. Bullae secondary infection
  3. Giant Bullous Emphysema (Vanishing Lung Syndrome)
    1. Large bullae, in some cases filling the entire hemithorax
    2. May impair lung function

VII. Resources

VIII. References

  1. Kumar and Kotloff (2018) Diagnostic Approach to the Adult with Cystic Lung Disease, UpToDate, accessed 8/5/2019
  2. Collins and Stern (2008) Chest Radiology, Wolters Kluwer, Philadelphia, p. 234-5

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Ontology: Bulla of lung (C0241982)

Concepts Disease or Syndrome (T047)
SnomedCT 162975005, 278976004
Italian Bolla del polmone
Japanese 肺胞内嚢胞, ハイホウナイノウホウ
English Bullae, lung bleb, bulla lungs, bullae lung, bleb lungs, blebs lungs, lung blebs, blebs lung, lung bulla, bulla of lung, bullae lungs, lung bullae, pulmonary bulla, bleb lung, bulla lung, Pulmonary bulla, Emphysematous bulla of lung, Bulla of lung, Bulla of lung (finding), bulla; lung, lung; bulla
Czech Plicní bula
Hungarian Tüdő bulla
Dutch bulla; long, long; bulla, longblaas
Spanish bulla pulmonar (hallazgo), bulla pulmonar, Bulla pulmonar
Portuguese Bolha pulmonar
French Bulle pulmonaire
German Pulmonalblase