II. Management: Medications

  1. See Severe Preeclampsia
  2. Corticosteroids if Preterm delivery unavoidable and fetus Gestational age 24-34 weeks
    1. Betamethasone 12 mg IM every 24 hours for 2 doses or
    2. Dexamethasone 6 mg IM every 12 hours for 4 doses

III. Management: Delivery Gestational age goals

  1. Mild Preeclampsia
    1. Delivery at 37 weeks is preferred (as of 2015)
  2. Severe Preeclampsia
    1. Delivery after 32 to 34 weeks
    2. Based on Fetal Lung Maturity and Preeclampsia severity (see below)
  3. Severe refractory Preeclampsia with signs maternal or fetal deterioration (see below)
    1. Delivery in <24 hours regardless of Gestational age or Fetal Lung Maturity
    2. Attempt Corticosteroids

IV. Management: Indications for emergent delivery now regardless of Gestational age in Severe Preeclampsia

  1. Gestational age >34 weeks and Severe Preeclampsia
  2. Refractory, Severe Hypertension (>160/110 mmHg) at any Gestational age
  3. Maternal or fetal deterioration
  4. Eclampsia
  5. Pulmonary Edema
  6. Placental Abruption

V. Management: Indications for delivery after 48 hours of Corticosteroids (Gestational age 24-34 weeks) in Severe Preeclampsia

  1. Thrombocytopenia (Platelet Count <100k)
  2. Serum transaminase levels >2x normal
  3. Intrauterine Growth Retardation (IUGR <5th percentile)
  4. Severe oligohydramnios
  5. Umbilical artery reversed end-diastolic flow (Uteroplacental insufficiency)
  6. New or worsening renal dysfunction
  7. Non-reassuring fetal testing
  8. Other symptoms which may prompt early delivery
    1. Persistant severe Headache or visual changes
    2. Persistant severe Epigastric Pain or Emesis

VI. Management: Indications for cesarean delivery (Vaginal Delivery is otherwise preferred)

  1. Recurrent Seizures refractory to medical management
  2. Refractory, Severe Hypertension (>160/110 mmHg)
  3. Maternal or fetal deterioration without impending delivery
  4. Severe Preeclampsia with unfavorable Cervix <30 weeks gestation (expert opinion)

VII. Precautions

  1. Avoid epidural or spinal Anesthetic if Platelet Count <70k, Coagulopathy, Anticoagulants or antiplatelet agents

VIII. References

  1. Fontaine (2000) in ALSO, B:1-36
  2. Sibai in Gabbe (2002) Obstetrics, p. 945-74
  3. Leeman (2016) Am Fam Physician 93(2):121-7 [PubMed]
  4. Zamorski (2001) Clin Fam Pract 3:329-47 [PubMed]

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