II. Indications
- Acute Cholecystitis
- Biliary Diskinesia
- Acalculous Cholecystitis
III. Mechanism: Visualization of biliary tree (liver and gallbladder function)
- Hepatobiliary Iminodiacetic Acid (IDA) is normally taken up by the liver and excreted into the bile
- When tagged with Technetium-99, IDA can be visualized with a gamma camera
IV. Preparations: Technetium-99 Tracers
- HIDA Scan (Hydroxy-Iminodiacetic Acid)
- Replaced with other tracing agents (although scan still referred to as HIDA)
- Previously Serum Bilirubin determined the agent used (HIDA was used if Total Bilirubin <5-7 mg/dl)
- DISIDA Scan (Diisopropyl Iminodiacetic Acid)
- PIPIDA Scan (Paraisopropyl Iminodiacetic Acid)
- BrIDA Scan (bromo-2, 4,6-trimethylacetanilido Iminodiaceticacid)
V. Technique
- HIDA Scan (or DISIDA, PIPIDA or BrIDA Scan)
- Technetium-iminodiacetic acid analog injected IV (see preparations above)
- Technetium-iminodiacetic acid analog is absorbed and secreted into biliary tract by hepatocytes
- Cholecystokinin-HIDA Scan
- HIDA Scan is performed before and after Cholecystokinin (CCK) administration
- Cholecystokinin stimulates gallbladder contraction
- Assessment of gallbladder contractility and ejection fraction
- Symptoms reproduced with Cholecystokinin (CCK) injection are suggestive of Biliary Colic
VI. Interpretation
- Normal Billiary tract and Gallbladder
- Clear outline gallbladder and cystic duct in 2 hours
-
Cystic duct obstruction
- Failure to outline Gallbladder within 2 hours
VII. Efficacy: Acute Cholecystitis
- Test Sensitivity: 97%
- Test Specificity: 77%
- Negative Predictive Value: 99%
VIII. References
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Definition (MSH) | A radiopharmaceutical used extensively in cholescintigraphy for the evaluation of hepatobiliary diseases. (From Int Jrnl Rad Appl Inst 1992;43(9):1061-4) |
Concepts | Indicator, Reagent, or Diagnostic Aid (T130) , Organic Chemical (T109) |
MSH | D019785 |
SnomedCT | 3040004 |
English | 99m Tc Disofenin, 99m-Tc-Disofenin, 99mTc DISIDA, 99mTc Disofenin, 99mTc-DISIDA, 99mTc-Disofenin, Acid, Technetium-99m-Diisopropyliminodiacetic, Disofenin, Tc-99m, Tc 99m Disofenin, Tc-99m Disofenin, Technetium 99m Diisopropyliminodiacetic Acid, Technetium 99m Disofenin, Technetium Tc 99m Disofenin, Technetium-99m-Diisopropyliminodiacetic Acid, Technetium-99m-Disofenin, TECHNETIUM TC DISOFENIN 099M, TC DISIDA, Technetium Tc^99c^ disofenin, Technetium Tc<sup>99m</sup> disofenin, Technetium Tc^99c^ disofenin (substance), Technetium Tc^99m^ disofenin (substance), Technetium Tc99m disofenin (substance), Technetium Tc99m disofenin, Technetium Tc<sup>99c</sup> disofenin (substance), Technetium Tc<sup>99m</sup> disofenin (substance), Technetium Tc<sup>99c</sup> disofenin, Technetium Tc^99m^ disofenin, Technetium Tc99c disofenin (substance), Technetium Tc99c disofenin, Technetium Tc-99m Disofenin, Technetium Tc 99m Disofenin [Chemical/Ingredient], technetium (99mTc) disofenin, TECHNETIUM TC-99M DISOFENIN, TECHNETIUM Tc 99m DISOFENIN |
Swedish | Teknetium Tc 99m-disofenin |
Czech | technecium 99mTc-disofenin |
Finnish | Teknetium Tc 99m -disofeniini |
Russian | TEKHNETSII TC 99M DIZOFENIN, ТЕХНЕЦИЙ TC 99M ДИЗОФЕНИН |
German | TECHNETIUM TC DISOFENIN 099M, Technetium-Tc-99m-Disofenin |
Spanish | disofenina con tecnecio Tc^99m^ (sustancia), disofenina con tecnecio Tc<sup>99m</sup>, disofenina con tecnecio Tc^99c^ (sustancia), disofenina con tecnecio Tc<sup>99c</sup> (sustancia), disofenina con tecnecio Tc^99m^, disofenina con tecnecio Tc99m, disofenina con tecnecio Tc^99c^, disofenina con tecnecio Tc99m (sustancia), disofenina con tecnecio Tc<sup>99m</sup> (sustancia), disofenina con tecnecio Tc99c, disofenina con tecnecio Tc<sup>99c</sup>, disofenina con tecnecio Tc99c (sustancia), Disofenina de Tecnecio Tc 99m |
Polish | Disfenin znakowany izotopem technetu 99m Tc, Disofenin-technet 99m |
Japanese | 99mTc-ジソフェニン, テクネチウム99mジソフェニン, Tc 99mジソフェニン, テクネチウムTc99mジソフェニン |
French | Technétium (99mTc) disofénine, Disofénine de technétium (99mTc) |
Italian | Tecnezio Tc 99m disofenina |
Portuguese | Disofenina Tecnécio Tc 99m |
Ontology: Technetium Tc 99m Lidofenin (C0075958)
Definition (MSH) | A nontoxic radiopharmaceutical that is used in the clinical evaluation of hepatobiliary disorders in humans. (J Nucl Med 1977;18(10):997-1004) |
Concepts | Inorganic Chemical (T197) , Indicator, Reagent, or Diagnostic Aid (T130) |
MSH | D019780 |
SnomedCT | 7281000 |
English | 99m Tc Lidofenin, 99m-Tc-Lidofenin, 99mTc HIDA, 99mTc Lidofenin, 99mTc-HIDA, 99mTc-Lidofenin, Lidofenin, Tc-99m, Tc 99m Lidofenin, Tc-99m Lidofenin, Technetium 99m Lidofenin, Technetium Tc 99m 2,6-Dimethyl Iminodiacetic Acid, Technetium Tc 99m Lidofenin, Technetium-99m-Lidofenin, TC HIDA, TC LIDOFENIN 099M, TECHNETIUM TC LIDOFENIN 099M, Technetium Tc99c lidofenin, Technetium Tc^99m^ lidofenin, Technetium Tc99m lidofenin, Technetium Tc<sup>99m</sup> lidofenin, Technetium Tc^99m^ lidofenin (substance), Technetium Tc^99c^ lidofenin, Technetium Tc^99c^ lidofenin (substance), Technetium Tc99c lidofenin (substance), Technetium Tc99m lidofenin (substance), Technetium Tc<sup>99m</sup> lidofenin (substance), Technetium Tc<sup>99c</sup> lidofenin, Technetium Tc<sup>99c</sup> lidofenin (substance), Technetium Tc 99m Lidofenin [Chemical/Ingredient], 99mtc-hida, Technetium Tc 99m 2,6 Dimethyl Iminodiacetic Acid, technetium (99mTc) lidofenin |
Swedish | Teknetium Tc 99m-lidofenin |
Czech | technecium 99mTc-lidofenin |
Finnish | Teknetium Tc 99m -lidofeniini |
Russian | TEKHNETSII TC 99M LIDOFENIN, 99MTC-LIDOFENIN, 99MTC-ЛИДОФЕНИН, ТЕХНЕЦИЙ TC 99M ЛИДОФЕНИН |
German | TECHNETIUM LIDOFENIN 099M, TC LIDOFENIN 099M, 99mTc-Lidofenin, Technetium-99m-Lidofenin |
Spanish | lidofenina marcada con tecnecio Tc^99m^ (sustancia), lidofenina con tecnecio Tc<sup>99c</sup> (sustancia), lidofenina con tecnecio Tc^99c^, lidofenina marcada con tecnecio Tc<sup>99m</sup>, lidofenina con tecnecio Tc^99c^ (sustancia), lidofenina marcada con tecnecio Tc<sup>99m</sup> (sustancia), lidofenina marcada con tecnecio Tc99m, lidofenina con tecnecio Tc99c (sustancia), lidofenina con tecnecio Tc99c, lidofenina con tecnecio Tc<sup>99c</sup>, lidofenina marcada con tecnecio Tc99m (sustancia), lidofenina marcada con tecnecio Tc^99m^, 99mTc-Lidofenina, Lidofenina de Tecnecio Tc 99m |
Polish | Lidofenin-technet 99m, Lidofenin znakowany radioizotopem 99m technetu |
Japanese | テクネチウム99mリドフェニン, テクネチウムTc99mリドフェニン, 99mTc-リドフェニン, Tc 99mリドフェニン |
French | Lidofénine de technétium (99mTc), Technétium (99mTc) lidofénine |
Italian | Tecnezio Tc 99m lidofenina |
Portuguese | Lidofenina-99mTc, Lidofenina Tecnécio Tc 99m |
Ontology: technetium Tc 99m mebrofenin (C0075962)
Definition (NCI) | A radioconjugate composed of the iminodiacetic acid derivative mebrofenin bound to an isotope of the synthetic element technetium (Tc). Upon administration and rapid clearance from the circulation, technetium Tc 99m mebrofenin is secreted into the hepatobiliary system, emitting gamma rays that are detectable with planar scintigraphy or single photon emission computer tomography (SPECT). Mebrofenin has no pharmacological effect at the recommended dosage for diagnostic imagining. |
Concepts | Inorganic Chemical (T197) , Indicator, Reagent, or Diagnostic Aid (T130) |
MSH | C034837 |
SnomedCT | 4832001 |
English | Tc-99m-3-bromo-2,4,6-trimethyl-IDA, Tc-99m-3-bromo-2,4,6-trimethyliminodiacetic acid, Tc-99m-BTM-IDA, Tc-99m-N-(2,4,6-trimethylbromoacetanilide)iminodiacetate, Tc-99m-SQ 26,962, Tc-99m-trimethylbromo-IDA, Tc-TMB-IDA, technetium Tc 99m 3-bromo-2,4,6-trimethyliminodiacetic acid, technetium Tc 99m mebrofenin, technetium Tc 99m-trimethylbromo-IDA, Tc-99m-TBIDA, Tc-99m-trimethylbromoimino-diacetic acid, Tc-99m-trimethylbromoiminodiacetate, Tc-99m-Br-IDA, Tc-99m-BrIDA, Tc-99m-trimethyl-BrIDA, Tc 99m Mebrofenin, Tc 99m MEB, Technetium Tc99c mebrofenin, Technetium Tc<sup>99c</sup> mebrofenin, Technetium Tc99m mebrofenin, Technetium Tc<sup>99c</sup> mebrofenin (substance), Technetium Tc^99m^ mebrofenin (substance), Technetium Tc<sup>99m</sup> mebrofenin (substance), Technetium Tc<sup>99m</sup> mebrofenin, Technetium Tc^99c^ mebrofenin (substance), Technetium Tc99c mebrofenin (substance), Technetium Tc^99c^ mebrofenin, Technetium Tc^99m^ mebrofenin, Technetium Tc99m mebrofenin (substance), Tc-99m Mebrofenin, Technetium Tc-99m Mebrofenin, 99mTc mebrofenin, technetium (99mTc) mebrofenin, TECHNETIUM TC-99M MEBROFENIN |
Spanish | mebrofenina con tecnecio Tc<sup>99c</sup>, mebrofenina con tecnecio Tc<sup>99c</sup> (sustancia), mebrofenina marcada con tecnecio Tc<sup>99c</sup>, mebrofenina con tecnecio Tc^99c^ (sustancia), mebrofenina con tecnecio Tc99c (sustancia), mebrofenina con tecnecio Tc^99c^, mebrofenina con tecnecio Tc99c, mebrofenina marcada con tecnecio Tc99c (sustancia), mebrofenina marcada con tecnecio Tc<sup>99c</sup> (sustancia), mebrofenina marcada con tecnecio Tc^99c^, mebrofenina marcada con tecnecio Tc99c, mebrofenina marcada con tecnecio Tc^99c^ (sustancia) |
Ontology: technetium Tc 99m PIPIDA (C0075979)
Concepts | Indicator, Reagent, or Diagnostic Aid (T130) , Organic Chemical (T109) |
MSH | C003693 |
English | Tc-99m-iprofenin, Tc-99m-paraisopropyl acetanilido IDA, Tc-99m-PIPIDA, technetium iprofenin, technetium p-isopropyl IDA, technetium p-isopropylacetanilidoiminodiacetic acid, technetium PIPIDA, technetium Tc 99m PIPIDA |
Ontology: Radionuclide biliary patency study (C0203762)
Concepts | Diagnostic Procedure (T060) |
SnomedCT | 28303002 |
Dutch | cholescintigrafie, HIDA-scan |
French | Cholescintigraphie, Scintigraphie HIDA |
German | Choleszintigraphie, HIDA-Szintigraphie |
Italian | Colecistoscintigrafia, HIDA scan |
Portuguese | Colescintigrafia, Colescintigrafia hapatobiliar |
Spanish | Colescintigrafía, estudio de la permeabilidad biliar por radionúclidos, Gammagrafía hepatobiliar con HIDA, estudio de la permeabilidad biliar por radionúclidos (procedimiento), estudio de la permeabilidad biliar por radiosótopos (procedimiento), estudio de la permeabilidad biliar por radiosótopos |
Japanese | 胆道シンチグラフィ, タンドウシンチグラフィ, HIDAスキャン, HIDAスキャン |
English | HIDA scan (procedure), isotopic scans liver HIDA, cholescintigraphy, hida scans, hida scan, Radionuclide biliary patency study, HIDA scan, Radionuclide biliary patency study (procedure), Cholescintigraphy |
Czech | HIDA snímek, Cholescintigrafie |
Hungarian | HIDA vizsgálat, Cholescintigraphia |
Ontology: Radionuclide hepatobiliary study with CCK (C0412403)
Concepts | Diagnostic Procedure (T060) |
SnomedCT | 241345000 |
English | RN hepatobiliary with CCK, Radionuclide hepatobiliary study with cholecystokinin (procedure), Radionuclide hepatobiliary study with CCK (procedure), Radionuclide hepatobiliary study with cholecystokinin, HIDA study with sincalide, Radionuclide hepatobiliary study with CCK |
Spanish | estudio hepatobiliar radioisotópico con colecistoquinina (procedimiento), estudio hepatobiliar radioisotópico con colecistoquinina |