II. Epidemiology

  1. Seen primarily in advanced HIV in Caribbean, SW USA

III. Pathophysiology

  1. Gastrointestinal infection

IV. Differential Diagnosis

V. Diagnosis

  1. Stool acid fast stain

VI. Management

  1. Trimethoprim-sulfamethoxazole (Bactrim, Septra, TMP-SMZ) DS
    1. Dose: Septra DS one tab twice daily for 7-10 days
    2. Longer course (for 3-4 weeks) or increased frequency (four times daily) may be required in HIV or AIDS
  2. Alternative agents
    1. Pyrimethamine 50 to 75 mg orally daily and folinic acid 10-25 mg orally daily
    2. Ciprofloxacin 500 mg twice daily for 7 days (limited evidence)

VII. Course

  1. Relapse in 50% of patients
  2. Chronic suppressive therapy may be necessary
    1. Example: Septra DS 1 tab orally three times weekly or once orally daily

VIII. References

  1. Gilbert (2016) Sanford Guide, on IOS, accessed 9/12/2016

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Ontology: Isospora belli (C0022254)

Concepts Eukaryote (T204)
SnomedCT 12633005
Dutch Isospora belli
French Isospora belli
German Isospora belli
Italian Isospora belli
Portuguese Isospora belli
Japanese イソスポーラ・ベリ, イソスポーラベリ
English Isospora belli, Cystoisospora belli, isospora belli, Isospora belli (organism)
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Ontology: Isosporiasis (C0311386)

Definition (MSH) Infection with parasitic protozoa of the genus ISOSPORA, producing intestinal disease. It is caused by ingestion of oocysts and can produce tissue cysts.
Concepts Disease or Syndrome (T047)
MSH D021865
ICD10 A07.3
SnomedCT 73034009, 360427001, 240373006, 371423007
LNC LA10479-6
Japanese イソスポーラ症, イソスポーラショウ
Swedish Isosporiasis
Czech isosporiasis, izosporóza, Izosporóza
Finnish Isosporiaasi
English isosporiasis (diagnosis), isosporiasis, Isosporiasis [Disease/Finding], isosporosis, Isosporiases, Isosporosis, Isosporiasis (disorder), Isosporiasis, Isosporiasis (disorder) [Ambiguous], Infection by Isospora belli and Isospora hominis
Korean 등포자충증
Polish Izosporoza, Zarażenie Isospora
Hungarian isosporiasis
Spanish isosporosis, isosporiasis (concepto no activo), isosporiasis (trastorno), isosporiasis, Isosporiasis
Dutch isosporiasis, Isosporiasis
French Isosporose, Isosporidiose
German Isosporiasis, Isosporose, Isospora-Infektion
Italian Isosporiasi
Portuguese Isosporíase