II. Signs

  1. Softening or cracking and fissuring at commissure
  2. Associated with erythema and crusts

III. Etiologies

  1. Underlying systemic disease
  2. Riboflavin deficiency
  3. Over-closure of mouth without teeth or with dentures

IV. Complications

  1. Secondary infection with Candida (Perleche) or Bacteria

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