II. Epidemiology
- Rare
III. Pathophysiology
-
Neutrophilic dermatosis
- Also occurs in Behcet Disease and Sweet Syndrome
- Neutrophils release elastase and other enzymes that result in skin breakdown
IV. Symptoms
- Painful Pustules and ulcers that form on the legs, buttocks, Abdomen and face in response to minor Skin Trauma
V. Signs
- Lesion characteristics
- Distribution (in order of most common to least common)
- Legs
- Buttocks
- Abdomen
- Face
-
Pathergy
- See Pathergy Test
- Blistering and ulceration in response to minor Trauma
- Also seen with Behcet Disease
VI. Associated Conditions
- Inflammatory Bowel Disease (e.g. Crohn's Disease, Ulcerative Colitis)
- Arthritis
- Hematologic Malignancy (e.g. Multiple Myeloma, Leukemia)
- Hepatitis
VII. Differential Diagnosis
- See Skin Ulcer
VIII. References
- Fitzpatrick (1992) Color Atlas and Synopsis of Clinical Dermatology
- Jhun and DeClerck in Herbert (2015) EM:Rap 15(8): 19-20
- Heiner (2015) Ann Emerg Med 66(2):115-8 [PubMed]