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Hypertension

Electrocardiogram

Hypotension

Hyperlipidemia

Coronary Artery Disease

Pericardial Disorders

Congestive Heart Failure

Examination

Inotrope

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Selective Aldosterone Receptor Antagonist

Aka: Selective Aldosterone Receptor Antagonist, Selective Aldosterone Blocker, Eplerenone, Inspra
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  1. Mechanism
    1. Selective Aldosterone Receptor Antagonist
    2. More selective for aldosterone than Spironolactone
  2. Indication
    1. Congestive Heart Failure
    2. Hypertension
  3. Contraindications
    1. Serum Potassium >5.5 mEq/L
    2. Tyep II Diabetes Mellitus with Microalbuminuria
    3. Renal insufficiency
      1. Serum Creatinine >2.0 in men or >1.8 mg/dl in women
      2. Creatinine Clearance <50 ml/min
  4. Adverse Effects
    1. Hyperkalemia
    2. Hypertriglyceridemia
    3. Hyponatremia
    4. Dizziness
    5. Fatigue
    6. Diarrhea
    7. Cough
    8. Less Gynecomastia and Impotence than Spironolactone
  5. Drug Interactions
    1. Potassium supplements
    2. Potassium sparing Diuretics
    3. Cytochrome P450 3A4 inhibitors (e.g. Ketoconazole)
    4. ACE Inhibitors
  6. References
    1. (2003) Lexi-Comp Drug Database
    2. (2003) Med Lett Drugs Ther 45(1156):39-40
    3. Stier (2003) Heart Dis 5(2):102-18
Medication Costs
Eplerenone (on 2/9/2012 at DrugStore.com)
Eplerenone 25mg Tablets #30 for $99.99 ($3.33/unit)
Eplerenone 50mg Tablets #30 for $99.99 ($3.33/unit)
Inspra (on 2/9/2012 at DrugStore.com)
Inspra 25mg Tablets #30 for $146.87 ($4.90/unit)
Inspra 50mg Tablets #30 for $149.04 ($4.97/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

eplerenone (C0961485)

Definition (NCI) A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerenone is used in the treatment of hypertension and congestive heart failure.
Concepts Steroid (T110) , Pharmacologic Substance (T121)
MSH C414690
SnomedCT 398699008, 407010008
English 9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, Methyl Ester, eplerenone (medication), eplerenon, EPLERENONE, eplerenone [Chemical/Ingredient], eplerenone, Eplerenone (product), Eplerenone (substance), Eplerenone
Spanish eplerenona (producto), eplerenona (sustancia), eplerenona
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Inspra (C1144054)

Concepts Steroid (T110) , Pharmacologic Substance (T121)
MSH C414690
English Inspra, Pfizer brand of eplerenone, inspra
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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