II. Mechanism
- See PCSK9 Inhibitor
- Human Monoclonal Antibody (PCSK9 Inhibitor)
III. Indications
- Severe familial Hypercholesterolemia (e.g. LDL Cholesterol >190 mg/dl)
IV. Dosing
- Store in refrigerator at 36 to 46 degrees
- May also store in original carton up to 30 days at room Temperature <77 F
- Administer subcutaneously in the Abdomen, back of the upper arm or the thigh
- Warm to room Temperature for 30 to 40 minutes before use
- Administration of full dose may require 10 to 20 seconds
- Start 75 mg SC every 2 weeks
- Maximum
- Every 2 weeks: 150 mg SC
- Every 4 weeks: 300 mg SC (2 doses injected at different sites)
V. Efficacy
- See PCSK9 Inhibitor
- Lower LDL Cholesterol up to 45 to 48% when added to a Statin
VI. Disadvantages
- See PCSK9 Inhibitor
- Costs $450 per 2 weeks (>$10,000 per year) in 2022
VII. Safety
- Unknown safety in pregnancy
- Unknown safety in Lactation
VIII. Resources
IX. References
- (2015) Presc Lett 22(9): 50-1
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
- (2022) Non-StatinLipid Lowering Agents, Presc Lett, #380202
- (2022) Med Lett Drug Ther 64(1659): 145-52
- Robinson (2015) N Engl J Med 372(16):1489-99 +PMID:25773378 [PubMed]
- Stroes (2014) J Am Coll Cardiol 63(23):2541-8 [PubMed]
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