II. Indications
III. Dosing: Adults
- Background
- Tablets are extended release
- Swallow whole and do not crush or chew
- Take on an empty Stomach or with a light meal
- Start 2.5 to 5 mg orally daily
- Target 5 to 10 mg orally daily
- Maximum 10 mg/day
IV. Mechanism
- See Dihydropyridine Calcium Channel Blocker
- Peripheral Vasodilation
- Increases myocardial contractility and Cardiac Output
V. Adverse Effects
- See Dihydropyridine Calcium Channel Blocker
- Appears safe in Congestive Heart Failure with Reduced Ejection Fraction
- Peripheral Edema
- Flushing
- Headache
- Dizziness
VI. Safety
- Pregnancy Category C
- Unknown Safety in Lactation
VII. Drug Interactions
- Felodipine Levels lowered by strong CYP3A4 Inhibitors (Ketoconazole, Itraconazole, Erythromycin)
- Digoxin levels are increased by Felodipine
VIII. Pharmacokinetics
- Slow onset of action (2 to 5 hours)
IX. Resources
- Felodipine Extended Release Tablet (DailyMed)
X. References
- (2022) Presc Lett, Resource #381108, Comparison of Calcium Channel Blockers
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 70-1
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
| felodipine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| FELODIPINE ER 10 MG TABLET | Generic | $0.21 each |
| FELODIPINE ER 2.5 MG TABLET | Generic | $0.18 each |
| FELODIPINE ER 5 MG TABLET | Generic | $0.21 each |