II. Indications
- See ACE Inhibitor
III. Mechanism
- See ACE Inhibitor
- Phosphinic acid-containing Angiotensin Converting Enzyme (ACE) inhibitor
- Fosinopril is a prodrug, converted to its active form Fosinoprilat via hydrolysis by esterases
IV. Dosing: Adults
- Adequate 24 hour Blood Pressure control may require twice daily dosing
-
Hypertension
- Start 10 mg orally daily or divided twice daily
- Start 5 mg orally daily if elderly, renal dysfunction or concurrent Diuretic
- Target 20 mg to 40 mg/day
- Maximum 80 mg/day (no added benefit for doses >40 mg/day)
- Start 10 mg orally daily or divided twice daily
-
Congestive Heart Failure (CHF)
- Start 5 to 10 mg orally daily
- Target 20-40 mg/day
- Maximum: 40 mg/day
-
Diabetic Nephropathy (not FDA approved)
- Take 10 to 20 mg orally daily
V. Dosing: Children (age 6 to 16 years old, weight >=50 kg)
- Contraindicated in age <6 years old or weight <50 kg
-
Hypertension
- Give 5 to 10 mg orally daily
VI. Supplied
- Available as scored tablets (10 mg) and unscored tablets (20 and 40 mg)
VII. Metabolism
- Excretion both renal and hepatic
VIII. Adverse Effects
- See ACE Inhibitor
IX. Safety
- See ACE Inhibitor
- Pregnancy Category X
- Avoid in Lactation
X. Resources
XI. References
- (2016) Presc Lett, Resource #321151, ACE Inhibitor Antihypertensive Dose Comparison
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 68-9
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
Images: Related links to external sites (from Bing)
Related Studies
| fosinopril (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| FOSINOPRIL SODIUM 10 MG TAB | Generic | $0.17 each |
| FOSINOPRIL SODIUM 20 MG TAB | Generic | $0.17 each |
| FOSINOPRIL SODIUM 40 MG TAB | Generic | $0.21 each |
| FOSINOPRIL-HYDROCHLOROTHIAZIDE 10-12.5 MG TAB | Generic | $0.32 each |
| FOSINOPRIL-HYDROCHLOROTHIAZIDE 20-12.5 MG TAB | Generic | $0.65 each |