II. Indications
- See Loop Diuretic
- Ethacrynic Acid is the only Loop Diuretic that is not a Sulfonamide
III. Mechanism
- See Loop Diuretic
IV. Dosing: Adult
- Oral
- Start: 25 mg orally daily
- Increase to 50 mg orally twice daily after first day
- Increase to 100 mg orally in the AM and 50 to 100 mg orally in PM
- Maximum: 200-400 mg divided twice daily
- Onset: 30 minutes
- Duration: 6 to 8 hours
- Intravenous
- Infusion concentration: 50 mg/ml
- Start: 0.5 to 1 mg/kg IV slowly over 20 to 30 minutes
- Maximum: 100 mg/dose
- IV Dose in 2023 costs $2500 in U.S.
- Onset: 5 minutes
- Duration: 2 hours
V. Dosing: Child
- Not FDA approved for use in children, and avoid in infants
- IV: 1 mg/kg IV
VI. Adverse Effects
- See Loop Diuretic
-
Ototoxicity
- Most potentially ototoxic of the Loop Diuretics
VII. Safety
- Pregnancy Category B
- Unknown Safety in Lactation
VIII. Drug Interactions
- Increases Lithium levels
IX. Resources
- Ethacrynic Acid Tablet (DailyMed)
- Ethacrynic Acid Intravenous Solution (DailyMed)
X. References
- (2021) Presc Lett, Resource #370507, Commonly Used Diuretics
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
Images: Related links to external sites (from Bing)
Related Studies
| ethacrynic acid (on 11/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ETHACRYNIC ACID 25 MG TABLET | Generic | $2.53 each |