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Labetalol

Aka: Labetalol, Trandate

See Also
1. Alpha Adrenergic Antagonist
2. Beta Blocker
Indications
1. Refractory Hypertension
  1. Very effective outpatient agent in oral form patients with Refractory Hypertension
2. Hypertensive Emergency
  1. Nicardipine has replaced intravenous Labetalol for Hypertensive Emergency
    1. Difficult to achieve Blood Pressure control in Hypertensive Crisis despite titration
    2. Short acting
  2. Labetalol is a preferred agent when compared with Hydaralazine and Clonidine
Mechanism
1. Combination of classes
  1. Alpha Adrenergic Antagonist and
  2. Nonselective Beta Blocker
2. Primary activity is as a negative inotrope
  1. Chronotropic effect is mild
Dosing
1. Oral: 100 mg PO bid (Maximum: 2400 mg/day)
2. Intravenous: 20 mg IV q10 minutes (Maximum: 200 mg)

Medication Costs
Labetalol HCl (on 2/9/2012 at DrugStore.com)
Labetalol HCl 100mg Tablets	#60 for $26.99	($0.45/unit)
Labetalol HCl 200mg Tablets	#30 for $16.99	($0.57/unit)
Labetalol HCl 300mg Tablets	#60 for $38.99	($0.65/unit)
Trandate (on 2/9/2012 at DrugStore.com)
Trandate 200mg Tablets	#60 for $66.99	($1.12/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Family Practice Notebook

Patients should address specific medical concerns with their physicians.

Although access to this page is not restricted, the information found here is intended for use by medical providers.

This page was written by Scott Moses, MD, last revised on 2/9/2012 and last published on 6/18/2013.

This is one of 5909 pages in the Family Practice Notebook