Cardiovascular Medicine Book

Hypertension

Electrocardiogram

Hypotension

Hyperlipidemia

Coronary Artery Disease

Pericardial Disorders

Congestive Heart Failure

Examination

Inotrope

Obstetrics Chapter related topics

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Nicardipine

Aka: Nicardipine
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  1. See Also
    1. Hypertensive Emergency
    2. Intravenous Antihypertensive
    3. Calcium Channel Blocker
  2. Indications
    1. First-line management of Hypertensive Emergency (Hypertensive Crisis)
      1. Preferred over Labetalol, Nitroglycerin Drip, and Nitroprusside
      2. Use Esmolol in Hypertensive Crisis if Heart Rate control is needed (e.g. AAA or Aortic Dissection)
  3. Mechanism
    1. Pure arterial vasodilation
    2. Decreases Blood Pressure
    3. Does not effect Heart Rate or preload
  4. Dosing
    1. Start: 5 mg/hour
    2. Maximum: 15 mg/hour
    3. Titrate
      1. Increase by 2.5 mg/hour every 5-15 minutes until Blood Pressure goal reached or maximum reached (15 mg/hour)
      2. Once goal Blood Pressure achieved, titrate down towards 3 mg/hour as long as Blood Pressure is controlled
  5. References
    1. Orman and Weingart in Majoewsky (2012) EM:RAP 12(2): 6-7
Medication Costs
NiCARdipine HCl (on 2/9/2012 at DrugStore.com)
NiCARdipine HCl 20mg Capsules #90 for $45.99 ($0.51/unit)
NiCARdipine HCl 30mg Capsules #90 for $60.99 ($0.68/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Nicardipine (C0028005)

Definition (MSH) A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
Definition (CSP) 1,4-dihydro-2,6-dimethyl-4-nitrophenyl-3, 5-pyridine carboxylic acid methyl-2- methylphenylmethylaminoethyl ester; calcium channel blocker of the nifedipine family; used clinically as a cerebral and coronary vasodilator.
Definition (NCI) A synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine Family) blocks calcium ions from certain cell walls and inhibits contraction of coronary and peripheral arteries, resulting in lowered oxygen requirements for heart muscle and decreased arterial contraction and spasm. It is used clinically as a cerebral and coronary vasodilator.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D009529
SnomedCT 108526002, 372502001
English Nicardipine, nicardipine, 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-(methyl(phenylmethyl)amino)ethyl ester, Nicardipine [Chemical/Ingredient], niCARdipine, Nicardipine (product), Nicardipine (substance), NICARDIPINE
Swedish Nikardipin
Czech nikardipin
Finnish Nikardipiini
Russian NIKARDIPIN, НИКАРДИПИН
Japanese ニカルジピン
Spanish nicardipino (sustancia), nicardipino, nicardipino (producto), nicardipina, nicardipina (producto), nicardipina (sustancia), Nicardipino
Polish Nikardypina
French Nicardipine
German Nicardipin
Italian Nicardipina
Portuguese Nicardipino
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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