II. Indications
III. Mechanism
- Aryloxypropanolamine derivative
- Nonselective Beta Blocker (Beta-1 and Beta-2 Adrenergic Blockade)
- Intrinsic Sympathomimetic activity (partial beta Agonist), similar to Acebutolol
- Also blocks Serotonin (5-HT) 1A receptors, increasing available CNS Serotonin with possible Antidepressant effects
IV. Dosing
- Start: 5 mg orally twice daily
- Target: 5 to 15 mg orally twice daily
- Maximum: 60 mg/day
V. Adverse Effects
- See Beta Blocker
VI. Safety
- Pregnancy Category B
- Unknown safety in Lactation
VII. Resources
VIII. References
- (2019) Presc Lett, Resource #350503, Comparison of Oral Beta Blockers
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 66-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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