Prostate Cancer Histologic grading

Aka: Prostate Cancer Histologic grading, Gleason Grading, Gleason Score

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II. Grading: Gleason Grade

  1. Score
    1. Grade dominant Prostate tumor on scale 1 to 5
    2. Grade other histologic patterns on scale 1 to 5
    3. Sum 2 grades for total score of 2 to 10 for tumor
  2. Interpretation: Prostate Cancer histology
    1. Grade 2 suggests highly differentiated tumor (best)
    2. Grade 10 suggests undifferentiated tumor (worst)

III. Grading: Grade Group (GG)

  1. Score
    1. Grade Group 1: Equivalent to Gleason Score of 6 (3+3)
    2. Grade Group 2: Equivalent to Gleason Score of 7 (3+4)
    3. Grade Group 3: Equivalent to Gleason Score of 7 (4+3)
    4. Grade Group 4: Equivalent to Gleason Score of 8 (4+4)
    5. Grade Group 5: Equivalent to Gleason Score of 9 or 10 (4+5 or 5+5)
  2. Interpretation
    1. GG1 lesions are associated with very low mortality
    2. Most Prostate Cancer Management is focused on GG2 and higher

IV. Reference

  1. Wilson (1991) Harrison's Internal Medicine, p. 1630
  2. Pierorazio (2013) BJU Int 111(5): 753-60 +PMID: 23464824 [PubMed]

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