II. Epidemiology
- Age of onset: 45 to 75 years old
- Contrast with other Bone Tumors (Osteosarcoma, Ewing Sarcoma) which have onset in teen years
III. Risk Factors
- Benign cartilage tumors (enchondroma, osteochondroma)
IV. Pathophysiology
- Malignant, cartilage producing Bone Tumor
- Originates in chondrocytes
-
Incidence: 1 in 200,000 in U.S.
- Least common Bone Cancer (behind Osteosarcoma, Ewing Sarcoma)
- Distribution
- Metastases
- Lungs
V. Imaging
- XRay
- Calcified eccentric lytic lesion
VI. Management
- Surgical resection
- First line management for localized and metastatic Chondrosarcoma
- Other management
- Radiation Therapy in cases of positive resection margins
- Chemotherapy is not indicated
- Chondrosarcoma does not respond to Chemotherapy
VII. Prognosis
- Grade 1: 90% five year survival
- Grade 2: 60-70% five year survival
- Grade 3: 30-50% five year survival
- Dedifferentiated: 10% survival at one year