II. Epidemiology

  1. Age of onset: 45 to 75 years old
    1. Contrast with other Bone Tumors (Osteosarcoma, Ewing Sarcoma) which have onset in teen years

III. Risk Factors

  1. Benign cartilage tumors (enchondroma, osteochondroma)

IV. Pathophysiology

  1. Malignant, cartilage producing Bone Tumor
    1. Originates in chondrocytes
  2. Incidence: 1 in 200,000 in U.S.
    1. Least common Bone Cancer (behind Osteosarcoma, Ewing Sarcoma)
  3. Distribution
    1. Central skeleton
    2. Pelvis
    3. Proximal long bones
    4. Scapula
    5. Ribs
  4. Metastases
    1. Lungs

V. Imaging

  1. XRay
    1. Calcified eccentric lytic lesion

VI. Management

  1. Surgical resection
    1. First line management for localized and metastatic Chondrosarcoma
  2. Other management
    1. Radiation Therapy in cases of positive resection margins
    2. Chemotherapy is not indicated
      1. Chondrosarcoma does not respond to Chemotherapy

VII. Prognosis

  1. Grade 1: 90% five year survival
  2. Grade 2: 60-70% five year survival
  3. Grade 3: 30-50% five year survival
  4. Dedifferentiated: 10% survival at one year

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