II. Pathophysiology

  1. Skin deposition of carotene

III. Causes

  1. Excessive Carotenoid (pigmented vegetable) ingestion
    1. Beta Carotene
    2. Licopene
    3. Xanthophyll
  2. Failure of liver to metabolize carotene
    1. Hypothyroidism (Myxedema)
    2. Diabetes Mellitus

IV. Symptoms

  1. Asymptomatic

V. Signs

  1. No Pigment in Sclera or Buccal mucosa
  2. Yellow pigmentation of skin (Carotenoderma)
    1. Nasolabial folds
    2. Forehead
    3. Behind ears
    4. Palms and soles

VI. Differential Diagnosis

VII. Labs

  1. Plasma Lipochrome elevated
  2. Blood carotene elevated

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Related Studies

Ontology: Hypercarotinemia (C0154271)

Definition (NCI) Increased serum carotenoids.
Concepts Disease or Syndrome (T047)
ICD9 278.3
ICD10 E67.1
SnomedCT 35487009
English Hypercarotenaemia, carotenemia, carotenemia (diagnosis), hypercarotenaemia, aurantiasis, Aurantiasis, Hypercarotinemia, Carotenemia, Carotenaemia, Hypercarotinaemia, Hypercarotinemia (disorder), carotene; excess, carotinosis, excess; carotene, hypercarotinemia
German Hyperkarotinaemie, Carotinaemie, Hypercarotinaemie
Korean 과카로틴혈증
Dutch hypercarotinemie, carotenemie, caroteen; overmaat, overmaat; caroteen, Hypercarotenemie
Spanish Carotenemia, Hipercarotinemia, aurantiasis, hipercarotinemia (trastorno), hipercarotinemia
Portuguese Carotenemia, Hipercarotinemia
Italian Ipercarotinemia, Carotenemia
French Caroténémie, Hypercarotinémie
Japanese カロチン血症, カロチンケッショウ, 高カロチン血症, コウカロチンケッショウ
Czech Karotenemie, Hyperkarotenemie
Hungarian Carotinaemia, Hypercarotinaemia

Ontology: Carotenoderma (C0238898)

Definition (NCI) Orange or yellow discoloration of the skin caused by excessive deposits of carotene.(NICHD)
Concepts Finding (T033)
SnomedCT 111401007
English Carotenoderma, Carotenosis cutis, Carotenosis cutis (disorder), Carotenosis cutis -RETIRED-, Carotenosis Cutis
Dutch carotenoderma
Spanish Carotenoderma, carotenosis cutis - RETIRADO - (concepto no activo), carotenosis cutis - RETIRADO -, carotenosis cutánea
Portuguese Carotenodermia
Italian Carotinoderma
German Karotenodermie
French Caroténodermie
Japanese 柑皮症, カンピショウ
Czech Karotenodermie
Hungarian Carotenoderma