II. Pathophysiology

  1. Skin deposition of carotene

III. Causes

  1. Excessive Carotenoid (pigmented vegetable) ingestion
    1. Beta Carotene
    2. Licopene
    3. Xanthophyll
  2. Failure of liver to metabolize carotene
    1. Hypothyroidism (Myxedema)
    2. Diabetes Mellitus

IV. Symptoms

  1. Asymptomatic

V. Signs

  1. No Pigment in Sclera or Buccal mucosa
  2. Yellow pigmentation of skin (Carotenoderma)
    1. Nasolabial folds
    2. Forehead
    3. Behind ears
    4. Palms and soles

VI. Differential Diagnosis

VII. Labs

  1. Plasma Lipochrome elevated
  2. Blood carotene elevated

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