II. Definition
- Congenital persistence of webbing between digits
III. Epidemiology
- Most common Congenital Anomaly of hand and foot
- Autosomal Dominant inheritance
IV. Pathophysiology
- Develops before 6 weeks post-conception
V. Signs
- Digits attached by persistent webbing
- Types of Attachment
- Simple Syndactyly: Digits attached only by skin
- Complicated Syndactyly: Adjacent bone or nail fused
- Length of finger in web
- Partial Syndactyly: Web extends from base partially
- Complete Syndactyly: Web from base to tip of finger
- Number of fingers involved
- Single Syndactyly: Involves 2 digits in web
- Double Syndactyly: Involves 3 digits in web
- Triple Syndactyly: Involves 4 digits in web
VI. Associated Conditions
- Apert's Syndrome
- Carpenter's Syndrome
- de Lange's Syndrome
- Holt-Oram Syndrome
- Orofaciodigital Syndrome
- Polysyndactyly
- Trisomy 13
- Trisomy 18
- Trisomy 21
- Fetal Hydantoin Syndrome
- Laurence-Moon-Biedl Syndrome
- Fanconi's Anemia
VII. References
- Behrman (2000) Nelson Pediatrics, Saunders, p. 2093
- Fuloria (2002) Am Fam Physician 65(2):265-70 [PubMed]