II. Indications
- Methicillin-Resistant Staphylococcus aureus (MRSA)
- Complicated Skin Infections
- Do not use for Pneumonia
- Poorly penetrates lung
- Inactivated by surfactant
III. Mechanism
- Cyclic Lipopeptide
- Depolarizes Bacterial cell membranes
IV. Preparations
- Intravenous daily dosing
V. Dosing: Adults
- Daptomycin 4 mg/kg in NS over 30 minutes once daily
VII. Monitoring
- Obtain serum CPK level weekly while on Daptomycin