II. Indications
- Activity
- Broad Gram Negative and Gram Positive coverage
- May cover organisms resistant to other antibiotics
- Methicillin-resistant Staphylococcus aureus
- Vancomycin-resistant Enterococcus species
- Acinetobacter baumannii
- ESBL Gram-Negative Bacteria
- Conditions
- Community Acquired Pneumonia
- Avoid in Hospital Acquired Pneumonia
- Avoid in Ventilator Associated Pneumonia
- Complicated Intraabdominal Infections
- Avoid in intestinal perforation
- Complicated Skin Infections
- Avoid in Diabetic Foot Infections
- Community Acquired Pneumonia
III. Contraindications
- Pregnancy
- Children age <8 years
- Relatively contraindicated as well in age <17 years
IV. Mechanism
- See Tetracyclines
- Broad-spectrum glycylcycline antibiotic derived from Tetracycline
V. Dosing: Adult
- Reconstituted Intravenous Fluid should have a yellow orange coloration
- Load: 100 mg IV infused over 30 to 60 minutes
- Next: 50 mg IV infused over 30 to 60 minutes every 12 hours
- Decrease dose to 25 mg IV in Child-Pugh C severe liver disease
VI. Dosing: Child
- Avoid in children in general unless no other alternative agent
- Absolutely contraindicated in children <8 years old
- Age 8 to 11 years
- Give 1.2 mg/kg (up to 50 mg) IV every 12 hours
- Age 12 to 17 years
- Give 50 mg IV every 12 hours
VII. Adverse Effects
- See Tetracyclines
- Nausea
VIII. Safety
- Pregnancy Category D
- Unknown safety in Lactation
IX. Drug Interactions
-
Warfarin
- May increase INR