II. Indications
III. Mechanism
- Nitroimidazole antiprotozoal agent
- Active against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia
- Metabolized to nitrite anions and Metronidazole
- Metronidazole in turn disrupts DNA helix, resulting in DNA breakage
- Final result is an inhibition of Protein synthesis in susceptible organisms
IV. Medications
- Tablets: 250 mg, 500 mg
- May be compounded into oral suspension by pharmacist
V. Dosing
-
Trichomoniasis
- Adult: 2 grams orally with food for single dose
-
Giardiasis
- Adult: 2 grams orally with food for single dose
- Child (age >3 years): 50 mg/kg (up to 2 grams) orally with food for one dose
-
Amebiasis
- Treatment for Amebic Dysentery or Liver Abscess should also include iodoquinol or Paromomycin
- Adult: 2 grams orally with food daily for 3 days
- Child (age >3 years): 50 mg/kg (up to 2 grams) orally with food daily for 3 days
-
Bacterial Vaginosis
- Adult: 2 grams orally with food daily for 2 days (or 1 g daily for 5 days)
VI. Safety
- Unknown safety in pregnancy
- Unknown safety in Lactation
- Consider pumping and dumping for first 3 days after a single dose
VII. Drug Interactions
-
Alcohol
- Disulfiram reaction
- Avoid Alcohol for at least 3 days after last Tinidazole dose
- Tinidazole may increase other drug levels
- Cyclosporine
- Fluorouracil
- Lithium
- Phenytoin
- Tacrolimus
- Warfarin (and increased INR)
-
Cholestyramine
- Separate dosing time from Tinidazole dose
VIII. Resources
Images: Related links to external sites (from Bing)
Related Studies
| tinidazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| TINIDAZOLE 500 MG TABLET | Generic | $2.60 each |