II. Indications
- See Topical Fluorouracil
- FDA Approved
- Off-Label Uses
- Anal Cancer
- Bladder Cancer
- Cervical Cancer
- Esophageal Cancer
- Head and Neck Cancer
- Hepatobiliary Cancer
- Nasopharyngeal Cancer (children)
- Neuroendocrine Tumors
- Penile Cancer
- Vulvar Cancer
- References
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
III. Mechanism
- Pyrimidine Antimetabolite Chemotherapy with antineoplastic activity
- Pyrimidine Analog of the Nucleoside uracil
- Fluoruracil is a prodrug converted to multiple active metabolites in vivo
- F-UMP (5-fluoroxyuridine monophosphate)
- F-dUMP (5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate)
- F-UMP incorporates into RNA, replacing uracil
- Inhibits RNA processing, Protein synthesis and cell growth
- F-dUMP inhibits thymidylate synthase
- Depletes thymidine triphosphate (TTP), a Nucleotide precursor
- With less TTP available, DNA synthesis is inhibited
IV. Medications
- Fluorouracil IV Solution: 500 mg, 2.5 g or 5 g vials
V. Dosing
- See other references for disease specific dosing protocols
VI. Adverse Effects
VII. Safety
- Avoid in Lactation
- Avoid in pregnancy (all trimesters)
- Use reliable Contraception
- Monitoring
- Complete Blood Count (CBC)
VIII. Drug Interactions
-
Warfarin
- Increased INR
IX. Resources
- Fluorouracil (DailyMed)
- Fluorouracil (StatPearls)
Images: Related links to external sites (from Bing)
Related Studies
| fluorouracil (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| FLUOROURACIL 2% TOPICAL SOLN | Generic | $3.61 per ml |
| FLUOROURACIL 5% CREAM | Generic | $0.87 per gram |
| FLUOROURACIL 5% TOPICAL SOLN | Generic | $5.94 per ml |