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Metronidazole
Aka: Metronidazole, Flagyl- Indications
- Protozoal Infection
- Anaerobic Bacteria infection
- Precautions
- Carcinogenic in mice and rats (FDA Black box warning)
- Pharmacokinetics
- Half-life: 8 hours
- Renal excretion
- Dosing: Children
- Dose
- Load: Metronidazole 15 mg/kg IV
- Maintenance: Metronidazole 7.5 mg/kg/dose
- Interval
- First week of life: q12 hours
- After first week of life: q 8hours
- Dose
- Dosing: Adult
- Intravenous
- Loading dose: 15 mg/kg up to 1000 mg IV
- Maintenance dose: 7.5 mg/kg up to 500 mg IV q6-8 hour
- Oral dose: 250 to 750 mg PO tid
- Intravenous
- Adverse Effects
- Antabuse like effect (Never use with Alcohol)
- Gastrointestinal intolerance
- Neurotoxicity (stop immediately if these occur)
- Seizures
- Encephalopathy
- Cerebellar dysfunction
- Peripheral Neuropathy (e.g. distal Paresthesias)
- Pregnancy
- Class B Medication (Avoid in first trimester pregnancy)
- Directions
- Taking with food decreases gastric irritation
- References
| Medication Costs | ||
|---|---|---|
| MetroNIDAZOLE (on 2/9/2012 at DrugStore.com) | ||
| MetroNIDAZOLE 0.75% Gel 45gm Tube | #1 for $49.99 | ($49.99/unit) |
| MetroNIDAZOLE 0.75% Cream 45gm Tube | #1 for $175.98 | ($175.98/unit) |
| MetroNIDAZOLE 0.75% Lotion 59ml Bottle | #1 for $240.00 | ($240.00/unit) |
| MetroNIDAZOLE 0.75% Gel 70gm Tube | #1 for $59.99 | ($59.99/unit) |
| MetroNIDAZOLE 250mg Tablets | #90 for $38.99 | ($0.43/unit) |
| MetroNIDAZOLE 500mg Tablets | #30 for $25.99 | ($0.87/unit) |
| Flagyl (on 2/9/2012 at DrugStore.com) | ||
| Flagyl 500mg Tablets | #30 for $189.00 | ($6.30/unit) |
| Flagyl 250mg Tablets | #30 for $112.99 | ($3.77/unit) |
| Flagyl 375mg Capsules | #30 for $142.80 | ($4.76/unit) |
| Flagyl ER (on 2/9/2012 at DrugStore.com) | ||
| Flagyl ER 750mg 24 Hour Tablets | #30 for $384.28 | ($12.81/unit) |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Metronidazole (C0025872) |
|
|---|---|
| Definition (CHV) | a drug that treats bacterial and fungal infection |
| Definition (CHV) | a drug that treats bacterial and fungal infection |
| Definition (NCI) | A drug that is used to treat infection and is being studied in the treatment of cancer. It is a type of antibacterial, antiprotozoal, and anthelmintic. |
| Definition (MSH) | A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed). |
| Definition (CSP) | antiprotozoal and antibacterial effective against obligate anaerobes. |
| Definition (PDQ) | A synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39503&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39503&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C651" NCI Thesaurus) |
| Definition (NCI) | A synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D008795 |
| SnomedCT | 326285001, 332974000, 1222004, 372602008 |
| English | 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-, Metronidazole [skin], 2 Methyl 5 nitroimidazole 1 ethanol, 2-Methyl-5-nitroimidazole-1-ethanol, Metronidazole, metronidazole, Metronizole, Metronidazole [vaginal], METRONIDAZOLE, Metronidazole [skin] (product), Metronidazole [vaginal] (product), metronidazole (medication), Metronidazole [Chemical/Ingredient], metronidazole vaginal, metroNIDAZOLE, Metronidazole product, Metronidazole (product), Metronidazole (substance), METRO, Metronidazole [skin] (substance), Metronidazole [vaginal] (substance) |
| Swedish | Metronidazol |
| Czech | metronidazol |
| Finnish | Metronidatsoli |
| Russian | METRONIDAZOL, МЕТРОНИДАЗОЛ |
| Spanish | metronidazol [uso vaginal], metronidazol (uso dermatológico) (producto), metronidazol [uso vaginal] (producto), metronidazol (uso dermatológico), metronidazol (piel) (producto), metronidazol (piel), metronidazol (producto), metronidazol (sustancia), metronidazol, Metronidazol |
| Japanese | フラジール, フラギル, 安息香酸メトロニダゾール, クロント, ダニゾール, メトロニダゾールホスファート, 塩酸メトロニダゾール, メトロニダゾール塩酸塩, メトロニダゾールベンゾアート, アスゾール, メトロニダゾール, メトロニダゾールリン酸, トリカゾール, ギネフラビル, トリバゾール |
| Polish | Metronidazol |
| French | Métronidazole |
| German | Metronidazol |
| Italian | Metronidazolo |
| Portuguese | Metronidazol |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Flagyl (C0699678) |
|
|---|---|
| Definition (CHV) | brand name of an antibiotic |
| Definition (CHV) | brand name of an antibiotic |
| Definition (NCI) | A drug that is used to treat infection and is being studied in the treatment of cancer. It is type of antibacterial, antiprotozoal, and anthelmintic. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D008795 |
| English | flagyl, flagyl [brand name], Flagyl |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |