Erythromycin Ethyl Succinate

Aka: Erythromycin Ethyl Succinate, Erythromycin EthylSuccinate, Erythromycin EES

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II. Mechanism

  1. See Erythromycin

III. Adverse Effects

  1. See Erythromycin

IV. Dosing

  1. Take with food to reduce gastrointestinal upset
  2. Adult: 400 mg orally four times daily
  3. Child: 30-50 mg/kg/day PO divided four times daily

V. Adverse Effects

  1. See Erythromycin
  2. Myasthenia Gravis exacerbation
  3. Hypertrophic Pyloric Stenosis (age <45 days)
  4. QT Prolongation
    1. Class effect with Macrolides
    2. Three fold increased risk of Sudden Cardiac Death while on Azithromycin
    3. Higher risk with known QTc Prolongation, Hypokalemia, Hypomagnesemia, Class IA or III Antiarrhythmics
    4. Ray (2013) N Engl J Med 366(20): 1881-90 [PubMed]

VI. Drug Interactions

  1. Strong CYP3A4 Inhibitor
    1. Numerous Drug Interactions
    2. Serious interactions resulting in death have occurred
  2. Warfarin
    1. May increase INR

VII. Safety

  1. Pregnancy Category B
  2. Considered safe in Lactation

VIII. Resources

  1. Erythromycin Ethyl Succinate Suspension (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3de1e0b9-473b-44c0-a644-5fa14ad69a83
  2. Erythromycin Ethyl Succinate Tablet (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=eb6ea746-3228-4969-8a26-653288662fd7

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