Infectious Disease Book

http://www.fpnotebook.com/

Second Generation FluoroquinoloneAka: Second Generation Quinolone, Ciprofloxacin, Ofloxacin, Norfloxacin

Advertisement

  1. See Also
    1. Fluoroquinolone
  2. Activity Spectrum (See Class I and Class II below)
    1. Gram Negative Rod coverage (see other Fluoroquinolones)
    2. Some atypical bacteria coverage (Class II only)
    3. See Ciprofloxacin below for other activity
  3. Preparations: Class I
    1. Indications
      1. Uncomplicated Urinary Tract Infections
    2. Similar spectrum to first generation agents
      1. Improved Gram Negative coverage over first generation
      2. Low systemic drug concentrations
    3. Agents
      1. Lomefloxacin (Maxaquin)
      2. Enoxacin (Penetrex)
      3. Norfloxacin (Noroxin)
  4. Preparations: Class II
    1. Indications
      1. Complicated Urinary Tract Infections
      2. Specific types of bacterial Gastroenteritis
      3. Prostatitis
      4. Sexually Transmitted Disease
      5. Avoid in community acquired Pneumonia
        1. Risk of pneumococcal bacteremia and Meningitis
    2. Additional Indications for Ciprofloxacin
      1. Pseudomonas aeruginosa
      2. Bacillus anthracis or Anthrax (first line agent)
      3. Vibrio Cholerae (Norfloxacin also covers)
      4. Yersinia pestis or Plague (first line agent)
      5. Tularemia (alternative medication)
    3. Significantly more active than Class I agents
      1. Broader Gram Negative coverage than Class I agents
      2. High systemic drug concentrations
      3. Some atypical bacteria coverage
      4. Pseudomonas aeruginosa (Ciprofloxacin only)
    4. Agents
      1. Ciprofloxacin (Cipro)
      2. Ofloxacin (Floxin)
  5. Directions
    1. Take on an empty stomach
    2. Take more than 1 hour before or two hours after food
  6. References
    1. King (2000) Am Fam Physician 61(9):2741
    2. O'Donnell (2000) Infect Dis Clin North Am 14(2):489
    3. Oliphant (2002) Am Fam Physician 65(3):455
    4. Owens (2000) Med Clin North Am 84(6):1447

Ciprofloxacin (C0008809)

Definition (MSH)A broad-spectrum antimicrobial carboxyfluoroquinoline.
Definition (NCI)An anti-infection drug that is also being studied in bladder cancer chemotherapy.
Definition (PDQ)A synthetic broad spectrum fluoroquinolone antibiotic. Ciprofloxacin binds to and inhibits bacterial DNA gyrase, an enzyme essential for DNA replication. This agent is more active against Gram-negative bacteria than Gram-positive bacteria. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40784&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40784&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C375" NCI Thesaurus)
Definition (CSP)broad spectrum antimicrobial carboxyfluoroquinoline.
Definition (NCI)A synthetic broad spectrum fluoroquinolone antibiotic. Ciprofloxacin binds to and inhibits bacterial DNA gyrase, an enzyme essential for DNA replication. This agent is more active against Gram-negative bacteria than Gram-positive bacteria. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD002939
EnglishCiprofloxacin, Ciprofloxacin ophthalmic preparation, Ciprofloxacin opthalmic preparation, CIPROFLOXACIN PREPARATION, Ciprofloxacin product, CPFX
Spanishciprofloxacina, preparado oftalmico con ciprofloxacina
Parent ConceptsQuinolones (C0034428), Anti-Bacterial Agents (C0279516), Fluoroquinolones (C0949665), Antitubercular Agents (C0003448), Topoisomerase-II Inhibitor (C1519554), Quinolone Compound (C1882518), [AM900] ANTI-INFECTIVES, OTHER (C0973485), [OP201] ANTIBACTERIALS, TOPICAL OPHTHALMIC (C0973596), Ciprofloxacin (C0008809), Ophthalmic antibiotic (C0304670), Quinolone Antibacterial Agents (C1533693), Duplicate concept (C1274013), Quinolones, Fluorinated (C1579343), Ophthalmic Antibacterials (C1579376)
SourcesAOD, CSP, LCH, LNC, MSH, MTHSPL, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Norfloxacin (C0028365)

Definition (MSH)A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
Definition (NCI)A synthetic, broad-spectrum fluoroquinolone with antibacterial activity. Norfloxacin inhibits activity of DNA gyrase, thereby blocking bacterial DNA replication. Norfloxacin concentrates in the renal tubules and bladder and is bactericidal against a wide range of aerobic gram-positive and gram-negative organisms.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD009643
EnglishNorfloxacin, NORFLOXACIN PREPARATION
Spanishnorfloxacina
Parent ConceptsFluoroquinolones (C0949665), Quinolone Compound (C1882518), Quinolones (C0034428), [AM900] ANTI-INFECTIVES, OTHER (C0973485), Quinolone Antibacterial Agents (C1533693), Ophthalmic form norfloxacin (C1720033), Quinolones, Fluorinated (C1579343)
SourcesLCH, LNC, MSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



Navigation Tree