Medication Causes of Constipation

Aka: Medication Causes of Constipation, Constipation due to Medication Causes, Drug-Induced Constipation

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II. Causes: Anticholinergic Agents

  1. Tricyclic Antidepressants
  2. Antipsychotics
  3. Antiparkinsonian agents (Levodopa)
  4. Antihistamines

III. Causes: Cation-containing agents

  1. Aluminum: Antacids, Sucralfate
  2. Calcium: Antacids, supplements
  3. Bismuth
  4. Iron Supplements

IV. Causes: Miscellaneous

  1. Antidiarrheal overuse
  2. Calcium Channel Blockers (Nifedipine, Verapamil)
  3. Clonidine
  4. Diuretics
  5. Cholestyramine
  6. NSAIDs
  7. Opiates (see Narcotic Related Constipation)
  8. Vinca Alkaloids
  9. Sympathomimetic agents
  10. Ganglion blockers

V. References

  1. Cheskin in Barker (1995) Ambulatory Med, p. 476-81
  2. Friedman (1991) Medical Diagnosis, p. 192-4
  3. Borum (2001) Prim Care 28(3):577-90 [PubMed]
  4. Sadler (2022) Am Fam Physician 106(3): 299-306 [PubMed]
  5. Wald (2000) Med Clin North Am 84(5):1231-46 [PubMed]

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