II. Mechanism
- Azapirone modulates Serotonin transmission
III. Dosing
- Start: 7.5 mg PO bid (or 5 mg PO tid)
- Effective dose: 20 to 30 mg per day
- Maximum: 60 mg per day
IV. Indications
-
Anxiety Disorders
- Generalized Anxiety Disorder
- Chronic Anxiety Disorder
- Anxiety in the elderly
- Aggression in developmentally disabled
- Agitated Dementia
- Emotional behavioral problems in brain injury
- Geriatric Depression
- Adjunctive use with SSRI in Major Depression
- Mixed anxiety and depression
- Enhance Major Depression response to SSRI
- Antidepressant Induced Sexual Dysfunction
-
Alcohol Withdrawal
- Reduces anxiety of "needing" a drink
- Obsessive Compulsive depression
- Use Buspar with Prozac
- Decreases Neuroleptic adverse effects
- Reduces Tardive Dyskinesia
- Reduces Akathisia
- Reduces Parkinsonism
V. Advantages compared with Benzodiazepines
- Non-addictive
- Less Sedation
- No associated memory Impairment
- No significant withdrawal syndrome
- Minimal Overdose potential
- No Anticholinergic Toxicity
- Well tolerated by elderly patients
VI. Disadvantages compared with Benzodiazepine
- Slow onset of action (takes 2-4 weeks until effect)
- Not useful in Panic Attacks
- No Sedative effect
- Requires repeat dosing 2-3 times per day
VII. Precautions
- Avoid use in pregnancy and Lactation
- Avoid in hepatic or renal Impairment
VIII. Adverse Effects
IX. Drug Interactions
- MAO inhibitors
- Haloperidol (Haldol)
- Cyclosporine (Sandimmune)
- Disulfiram (Antabuse)
-
Erythromycin and Itraconazole suppresses p450
- Results in Buspirone levels 5-13 times normal
X. Protocol to convert from Benzodiazepine to Buspirone
- Convert short-acting Benzodiazepine to long-acting
- Example: Alprazolam to Clonazepam
- Start Buspirone at above doses
- Taper long-acting Benzodiazepine over 60 to 90 days
Images: Related links to external sites (from Bing)
Related Studies
| Buspirone (on 6/18/2017 at Walmart.com) | ||
| Buspirone 10mg | #60 tablets for $4.00 | $0.07 each |
| Buspirone 10mg | #180 tablets for $10.00 | $0.06 each |
| Buspirone 5mg | #60 tablets for $4.00 | $0.07 each |
| Buspirone 5mg | #180 tablets for $10.00 | $0.06 each |
| buspirone (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| BUSPIRONE HCL 10 MG TABLET | Generic | $0.06 each |
| BUSPIRONE HCL 15 MG TABLET | Generic | $0.08 each |
| BUSPIRONE HCL 30 MG TABLET | Generic | $0.42 each |
| BUSPIRONE HCL 5 MG TABLET | Generic | $0.04 each |
| BUSPIRONE HCL 7.5 MG TABLET | Generic | $0.45 each |
Ontology: Buspirone (C0006462)
| Definition (NCI_NCI-GLOSS) | A drug that is used to treat certain anxiety disorders. It belongs to the family of drugs called antianxiety agents. |
| Definition (NCI) | An anxiolytic agent chemically and pharmacologically unrelated to benzodiazepines, barbiturates, or other sedative/hypnotic drugs. Although its exact mechanism of action is unknown, buspirone may exert its anti-anxiety effects via serotonin (5-HT1A) and dopamine receptors (D2) and may indirectly affect other neurotransmitter systems. Unlike typical benzodiazepine anxiolytics, this agent does not exert anticonvulsant or muscle relaxant effects and lacks prominent sedative effects. |
| Definition (MSH) | An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM. |
| Definition (CSP) | 8-(4-(2-pyrimidinyl)-1-piperazinyl) butyl-8-azaspirodecane-7,9- dione; serotonergic tranquilizer frequently contrasted with benzodiazepine-type, GABAergic tranquilizers. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D002065 |
| SnomedCT | 387523009, 91452003 |
| LNC | LP17859-7, MTHU024715 |
| English | Buspirone, N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide, 8-Azaspiro(4.5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, buspirone (medication), Buspirone [Chemical/Ingredient], BUSPIRONE, busPIRone, buspirone, Buspirone (product), Buspirone (substance) |
| Swedish | Buspiron |
| Czech | buspiron |
| Finnish | Buspironi |
| Russian | BUSPIRON, БУСПИРОН |
| Japanese | ブスピロン |
| Polish | Buspiron |
| Spanish | buspirona (producto), buspirona (sustancia), buspirona, Buspirona |
| French | Buspirone |
| German | Buspiron |
| Italian | Buspirone |
| Portuguese | Buspirona |
Ontology: Buspar (C0600122)
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D002065 |
| English | BuSpar, buspar, Bespar, Bristol Myers Brand of Buspirone Hydrochloride, Bristol Myers Squibb Brand of Buspirone Hydrochloride, Bristol-Myers Brand of Buspirone Hydrochloride, Bristol-Myers Squibb Brand of Buspirone Hydrochloride, Hormosan Brand of Buspirone Hydrochloride, UPSA Brand of Buspirone Hydrochloride, Buspar |
