Sulfonylurea

Aka: Sulfonylurea, Insulin Secretagogue

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II. Background

  1. Discovered in 1940's when investigating antibiotics

III. Mechanism

  1. Stimulates Potassium channel closure on pancreatic beta cell surface
  2. Results in Insulin release

IV. Types

  1. First Generation Sulfonylurea (Listed for historical purposes only)
  2. Second Generation Sulfonylurea (e.g. Glipizide, Glyburide)
  3. Non-Sulfonylurea Insulin Secretagogues (e.g. Meglitinide, Repaglinide)

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