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SulfonylureaAka: Insulin Secretagogue
- See Also
- Oral Hypoglycemic Agents
- Background
- Discovered in 1940's when investigating antibiotics
- Mechanism
- Stimulates potassium channel closure on pancreatic beta cell surface
- Results in Insulin release
- Types
- First Generation Sulfonylurea (Listed for historical purposes only)
- Second Generation Sulfonylurea (e.g. Glipizide, Glyburide)
- Non-Sulfonylurea Insulin Secretagogues (e.g. Meglitinide, Repaglinide)
Sulfonylurea Compounds (C0038766) | |
|---|---|
| Definition (CSP) | compounds of the type R-SO2-NHCONH-; when R=Ph, these are a group of hypoglycemic agents which enhance insulin secretion by beta cells and insulin sensitivity in target tissue, and so are effective in type II (noninsulin-dependent) diabetes mellitus. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D013453 |
| English | Sulfonylurea, Sulfonylurea and its derivatives, Sulfonylurea Compounds, SULFONYLUREA CPDS, Sulfonylurea product, Sulfonylureas, Sulphonylurea, Sulphonylurea and its derivatives, Sulphonylurea compounds, Sulphonylurea product |
| Spanish | sulfonilurea, sulfonilurea y derivados |
| Parent Concepts | inorganic sulfur compounds (C0682919), Hypoglycemic Agents (C0020616), Sulfonamides (C0038760), Sulfones (C0038761), Urea (C0041942), Antidiabetics (C0935929), Organic sulfur compound (C0303848), Oral hypoglycemic (C0359086), Intermediary product of metabolism (C0443598), Sulfonylurea Compounds (C0038766), Duplicate concept (C1274013) |
| Sources | AOD, CSP, LNC, MSH, NDFRT, PDQ, SCTSPA, SNOMEDCT, USPMG Derived from the NIH UMLS (Unified Medical Language System) |
