Endocrinology Book

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Human Growth HormoneAka: Growth Hormone, hGH

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  1. Indications
    1. Medical Uses
      1. Used to enhance growth in Short Stature
    2. Illicit uses
      1. Ergogenic Aid used by athletes
      2. Similar effect as with Anabolic Steroids
        1. Difficult to detect
        2. Expensive (>$1000/month)
  2. Mechanism
    1. Liver converts GH to Insulin-like growth factor (IGF-1)
    2. Precursor to testosterone
  3. Source
    1. Initially derived from cadavers in 1950's
      1. Transmitted Creutzfeldt-Jakob Disease to patients
    2. Now produced by recombinant genetics
      1. Genentech developed Somatrem (Protropin) in 1990s
  4. Dosing
    1. Available only via injection
  5. Adverse Effects
    1. Growth-hormone induced Myopathy
      1. Muscles hypertrophy, but are weaker than before
    2. Acromegaly
    3. Diabetes Mellitus
    4. Cardiomyopathy
    5. Congestive Heart Failure
    6. May be related to Leukemia development

Somatotropin (C0037663)

Definition (MSH)A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.
Definition (CSP)polypeptide that is secreted by the anterior pituitary gland; affects protein, carbohydrate and lipid metabolism; stimulates mitosis, cell differentiation and cell growth.
Definition (NCI)A peptide hormone secreted by the anterior lobe of the pituitary gland and regulates several physiologic processes, including growth and metabolism.
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Hormone (T125)
MSHD013006
EnglishGH, GH - Growth hormone, GHN, Growth Hormone, Growth Hormone 1, Growth hormone preparation, Growth hormone product, hGHN, Pituitary Growth Hormone, Somatotrophin, Somatotropic Hormone, Somatotropin, Somatotropin preparation, Somatrophic hormone, STH
Spanishhormona somatotrofica, hormona somatrofica, preparado de hormona del crecimiento, preparado de somatotrofina, preparado de somatotropina, preparado de STH
Parent ConceptsPolypeptide Hormones (C0312439), Pituitary Hormones (C0032015), Pituitary Hormones, Anterior (C0032016), Neuropeptides (C0027895), Unclassified Ingredient Preparations (C1377282), Somatotropin (C0037663), Hormones (C0019932)
SourcesAOD, CSP, LCH, LNC, MSH, MTH, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, UWDA, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Somatropin (C0169964)

Definition (MSH)A 191-amino acid polypeptide hormone secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR), also known as GH or somatotropin. Synthetic growth hormone, termed somatropin, has replaced the natural form in therapeutic usage such as treatment of dwarfism in children with growth hormone deficiency.
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Hormone (T125)
MSHD019382
EnglishBiosynthetic human growth hormone, GH - Growth hormone, Growth hormone, hGH, HGH - Growth hormone, Human Growth Hormone, Somatotrophin, Somatotropic hormone, Somatropin, SOMATROPIN PREPARATION
Spanishhormona de crecimiento, hormona del crecimiento, hormona del crecimiento humano, hormona somatotrofica, somatotrofina, somatotropina, somatropina
Parent ConceptsSomatotropin (C0037663), Pituitary Hormones, Anterior (C0032016), Recombinant Growth Hormone (C0376560), Recombinant Human Growth Hormone (Mammalian) (C0384570), Peptide hormones and their metabolites and precursors (C0582246), Ambiguous concept (C1274012), Duplicate concept (C1274013), Drug allergen (C1320237)
SourcesCSP, MSH, MTH, MTHSPL, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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