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Medications Associated with Weight Gain
Aka: Medications Associated with Weight Gain, Medications that exacerbate Obesity
- Preparations: Endocrine Agents
- Diabetes medications
- Most weight gain: Insulin, Sulfonylureas (Glyburide, Glipizide), Meglitinides, Thiazolidinediones
- Least weight gain: Acarbose, Exenatide, glimepiride, Glucophage, Miglitol, Pramlintide
- Tamoxifen
- Steroid hormones
- Glucocorticoids and Corticosteroids
- Progestational steroids
- Medications: Psychotropics
- Selective Serotonin Reuptake Inhibitors (SSRI), Tricyclic Antidepressants and atypicals
- Weight gain is associated with Histamine H1 receptor blockade
- Most weight gain: Tricyclic Antidepressants, Remeron, Paxil
- Least weight gain: Bupropion, Prozac
- Monoamine Oxidase Inhibitors (Phenelzine)
- Consider Tranylcypromine instead
- Phenothiazines
- Tricyclic Antidepressants (Amitriptyline, Imipramine, Nortriptyline)
- Consider Desipramine or protriptyline instead
- Atypical Antipsychotics (Clozapine, Olanzapine, Risperidone)
- Consider Aripiprazole (Abilify) or Ziprasidone (Geodon) instead
- Lithium
- Medications: Neurologic Agents
- Anticonvulsants
- Most weight gain: Valproic Acid, Gabapentin, Carbamazepine
- Least weight gain: Lamotrigine, Topiramate, Zonisamide
- Medications: Cardiovascular Agents
- Alpha adrenergic blockers
- Consider Doxazosin instead
- Beta adrenergic blockers (esp. Propranolol)
- Consider ACE Inhibitors, Angiotensin Receptor Blockers, Calcium Channel Blockers, selective Beta Blockers instead
- Preparations: Miscellaneous
- Highly active Antiretroviral therapy
- References
- Malone (2005) Ann Pharmacother 39(12): 2046-55